Efficient Skin Temperature Sensor and Stable Gel‐Less Sticky ECG Sensor for a Wearable Flexible Healthcare Patch
TL;DR: The effect of film thickness for skin temperature measurements, adhesive force, and reliability of gel-less ECG sensors as well as an integrated real-time demonstration is reported.
Abstract: Wearable, flexible healthcare devices, which can monitor health data to predict and diagnose disease in advance, benefit society. Toward this future, various flexible and stretchable sensors as well as other components are demonstrated by arranging materials, structures, and processes. Although there are many sensor demonstrations, the fundamental characteristics such as the dependence of a temperature sensor on film thickness and the impact of adhesive for an electrocardiogram (ECG) sensor are yet to be explored in detail. In this study, the effect of film thickness for skin temperature measurements, adhesive force, and reliability of gel-less ECG sensors as well as an integrated real-time demonstration is reported. Depending on the ambient conditions, film thickness strongly affects the precision of skin temperature measurements, resulting in a thin flexible film suitable for a temperature sensor in wearable device applications. Furthermore, by arranging the material composition, stable gel-less sticky ECG electrodes are realized. Finally, real-time simultaneous skin temperature and ECG signal recordings are demonstrated by attaching an optimized device onto a volunteer's chest.
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TL;DR: The latest advances in the rational design and controlled fabrication of carbon materials toward applications in flexible and wearable electronics are reviewed and various carbon materials with controlled micro/nanostructures and designed macroscopic morphologies for high-performance flexible electronics are introduced.
Abstract: Flexible and wearable electronics are attracting wide attention due to their potential applications in wearable human health monitoring and care systems. Carbon materials have combined superiorities such as good electrical conductivity, intrinsic and structural flexibility, light weight, high chemical and thermal stability, ease of chemical functionalization, as well as potential mass production, enabling them to be promising candidate materials for flexible and wearable electronics. Consequently, great efforts are devoted to the controlled fabrication of carbon materials with rationally designed structures for applications in next-generation electronics. Herein, the latest advances in the rational design and controlled fabrication of carbon materials toward applications in flexible and wearable electronics are reviewed. Various carbon materials (carbon nanotubes, graphene, natural-biomaterial-derived carbon, etc.) with controlled micro/nanostructures and designed macroscopic morphologies for high-performance flexible electronics are introduced. The fabrication strategies, working mechanism, performance, and applications of carbon-based flexible devices are reviewed and discussed, including strain/pressure sensors, temperature/humidity sensors, electrochemical sensors, flexible conductive electrodes/wires, and flexible power devices. Furthermore, the integration of multiple devices toward multifunctional wearable systems is briefly reviewed. Finally, the existing challenges and future opportunities in this field are summarized.
751 citations
TL;DR: This review summarizes the latest advances in this emerging field of "bio-integrated" technologies in a comprehensive manner that connects fundamental developments in chemistry, material science, and engineering with sensing technologies that have the potential for widespread deployment and societal benefit in human health care.
Abstract: Bio-integrated wearable systems can measure a broad range of biophysical, biochemical, and environmental signals to provide critical insights into overall health status and to quantify human performance. Recent advances in material science, chemical analysis techniques, device designs, and assembly methods form the foundations for a uniquely differentiated type of wearable technology, characterized by noninvasive, intimate integration with the soft, curved, time-dynamic surfaces of the body. This review summarizes the latest advances in this emerging field of “bio-integrated” technologies in a comprehensive manner that connects fundamental developments in chemistry, material science, and engineering with sensing technologies that have the potential for widespread deployment and societal benefit in human health care. An introduction to the chemistries and materials for the active components of these systems contextualizes essential design considerations for sensors and associated platforms that appear in f...
727 citations
TL;DR: Inspired by the fiber-reinforced microstructures and mechano-transduction systems of human muscles, a self-healing, long-lasting thermal tolerant and dual-sensory hydrogel-based sensor is proposed, with high gauge factor and a flexible touch keyboard for signature identification and a "fever indicator" for human forehead's temperature detection can be realized by this Hydrogel bioelectronic device.
Abstract: Recently, self-healing hydrogel bioelectronic devices have raised enormous interest for their tissue-like mechanical compliance, desirable biocompatibility, and tunable adhesiveness on bioartificial organs. However, the practical applications of these hydrogel-based sensors are generally limited by their poor fulfillment of stretchability and sensitivity, brittleness under subzero temperature, and single sensory function. Inspired by the fiber-reinforced microstructures and mechano-transduction systems of human muscles, a self-healing (90.8%), long-lasting thermal tolerant and dual-sensory hydrogel-based sensor is proposed, with high gauge factor (18.28) within broad strain range (268.9%), low limit of detection (5% strain), satisfactory thermosensation (-0.016 °C-1), and highly discernible temperature resolution (2.7 °C). Especially by introducing a glycerol/water binary solvent system, desirable subzero-temperature self-healing performance, high water-retaining, and durable adhesion feature can be achieved, resulting from the ice crystallization inhibition and highly dynamic bonding. On account of the advantageous mechanoreception and thermosensitive capacities, a flexible touch keyboard for signature identification and a "fever indicator" for human forehead's temperature detection can be realized by this hydrogel bioelectronic device.
395 citations
TL;DR: The ability of such systems to monitor glucose non-invasively offers an attractive route toward advancing the management of diabetes and achieving improved glycemic control, but realizing the potential diagnostic impact of these new epidermal sensing strategies would require extensive efforts toward addressing key technological challenges.
391 citations
TL;DR: In this article, the authors present a review of the latest advances in multifunctional wearable electronics, primarily including versatile multimodal sensor systems, self-healing material-based devices, and self-powered flexible sensors.
Abstract: DOI: 10.1002/admt.201800628 applications (e.g., soft robotics, medical devices).[1–6] Despite state-of-the-art bulkbased planar integrated-circuit devices, their rigid and brittle nature gives rise to the incompatibility with curvilinear and soft human bodies, restricting the development of newborn human-friendly interactive electronics. In contrast, the bendable and flexible wearable electronics could be conformally attached onto human bodies almost without discomfort and succeed in performing a great deal of sensing functionalities. Realization of such promising goals requires the flexible sensor platforms provided with crucial characteristics of light weight, ultrathinness, superior flexibility, stretchability, high sensitivity as well as rapid response.[7–10] Inspired by the perceptive features of human skins, the wearable sensor systems are capable of acquiring abundant information from the external environment with the assistance of sensing modules, such as pressure sensors, strain sensors, temperature sensors, etc.[11] A typical example is their application in prosthetics that could afford the capacity to perceive touch or temperature for the disabled.[12] Additionally, the wearable sensor systems are able to identify physical or chemical signals produced by the human body, providing promising opportunities to evaluate health states.[5,13–15] Conventional skin-like sensor platforms primarily comprise one or two sensing modules, data processing units, and power supplies. Their unitary functionality, however, cannot satisfy the increasing demands of IoTs. Recently, the rapid advances in novel sensing materials, fabrication strategies, and innovative electronic constitution contribute to the development of versatile integration of multimodal sensors, which could synchronously distinguish diverse stimuli from the complex environment and monitor multiple vital signs from the human body.[16,17] In spite of several attempts done in terms of such multimodal sensor systems, one of the cumbersome issues originates from the crosscoupling effect among different categories of signals simultaneously generated by various sensors. Furthermore, the skin-like multiple sensor systems usually suffer from the limited number of repeated use, resulting in their high use-cost. The development of separable versatile devices may address this issue with one layer realized by costeffective materials and fabrication manners for disposable use and the other composed of relatively expensive components for repeatable applications.[18] Additionally, the multiple bending or Skin-inspired wearable devices hold great potentials in the next generation of smart portable electronics owing to their intriguing applications in healthcare monitoring, soft robotics, artificial intelligence, and human–machine interfaces. Despite tremendous research efforts dedicated to judiciously tailoring wearable devices in terms of their thickness, portability, flexibility, bendability as well as stretchability, the emerging Internet of Things demand the skininterfaced flexible systems to be endowed with additional functionalities with the capability of mimicking skin-like perception and beyond. This review covers and highlights the latest advances of burgeoning multifunctional wearable electronics, primarily including versatile multimodal sensor systems, self-healing material-based devices, and self-powered flexible sensors. To render the penetration of human-interactive devices into global markets and households, economical manufacturing techniques are crucial to achieve large-scale flexible systems with high-throughput capability. The booming innovations in this research field will push the scientific community forward and benefit human beings in the near future.
377 citations
References
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TL;DR: This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.
Abstract: Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.
3,235 citations
TL;DR: In this paper, the authors present a platform that makes electronics both virtually unbreakable and imperceptible on polyimide polysilicon elastomers, which can be operated at high temperatures and in aqueous environments.
Abstract: Electronic devices have advanced from their heavy, bulky origins to become smart, mobile appliances. Nevertheless, they remain rigid, which precludes their intimate integration into everyday life. Flexible, textile and stretchable electronics are emerging research areas and may yield mainstream technologies. Rollable and unbreakable backplanes with amorphous silicon field-effect transistors on steel substrates only 3 μm thick have been demonstrated. On polymer substrates, bending radii of 0.1 mm have been achieved in flexible electronic devices. Concurrently, the need for compliant electronics that can not only be flexed but also conform to three-dimensional shapes has emerged. Approaches include the transfer of ultrathin polyimide layers encapsulating silicon CMOS circuits onto pre-stretched elastomers, the use of conductive elastomers integrated with organic field-effect transistors (OFETs) on polyimide islands, and fabrication of OFETs and gold interconnects on elastic substrates to realize pressure, temperature and optical sensors. Here we present a platform that makes electronics both virtually unbreakable and imperceptible. Fabricated directly on ultrathin (1 μm) polymer foils, our electronic circuits are light (3 g m(-2)) and ultraflexible and conform to their ambient, dynamic environment. Organic transistors with an ultra-dense oxide gate dielectric a few nanometres thick formed at room temperature enable sophisticated large-area electronic foils with unprecedented mechanical and environmental stability: they withstand repeated bending to radii of 5 μm and less, can be crumpled like paper, accommodate stretching up to 230% on prestrained elastomers, and can be operated at high temperatures and in aqueous environments. Because manufacturing costs of organic electronics are potentially low, imperceptible electronic foils may be as common in the future as plastic wrap is today. Applications include matrix-addressed tactile sensor foils for health care and monitoring, thin-film heaters, temperature and infrared sensors, displays, and organic solar cells.
2,062 citations
TL;DR: G graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy and can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice.
Abstract: Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene is a versatile material in micro- and macroelectronics. However, the low density of electrochemically active defects in graphene synthesized by chemical vapour deposition limits its application in biosensing. Here, we show that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene, sufficient to form a wearable patch for sweat-based diabetes monitoring and feedback therapy. The stretchable device features a serpentine bilayer of gold mesh and gold-doped graphene that forms an efficient electrochemical interface for the stable transfer of electrical signals. The patch consists of a heater, temperature, humidity, glucose and pH sensors and polymeric microneedles that can be thermally activated to deliver drugs transcutaneously. We show that the patch can be thermally actuated to deliver Metformin and reduce blood glucose levels in diabetic mice.
1,301 citations
TL;DR: Materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address technical challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate are described.
Abstract: Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.
1,201 citations
TL;DR: Carbon nanotubes (CNT) are well-ordered, high aspect ratio allotropes of carbon The two main variants, SWCNT and MWCNT, both possess a high tensile strength, are ultra-light weight, and have excellent chemical and thermal stability They also possess semi-and metallic-conductive properties as discussed by the authors.
885 citations