Proceedings Article•
EfficientL 1 regularized logistic regression
16 Jul 2006-pp 401-408
TL;DR: Theoretical results show that the proposed efficient algorithm for L1 regularized logistic regression is guaranteed to converge to the global optimum, and experiments show that it significantly outperforms standard algorithms for solving convex optimization problems.
Abstract: L1 regularized logistic regression is now a workhorse of machine learning: it is widely used for many classification problems, particularly ones with many features. L1 regularized logistic regression requires solving a convex optimization problem. However, standard algorithms for solving convex optimization problems do not scale well enough to handle the large datasets encountered in many practical settings. In this paper, we propose an efficient algorithm for L1 regularized logistic regression. Our algorithm iteratively approximates the objective function by a quadratic approximation at the current point, while maintaining the L1 constraint. In each iteration, it uses the efficient LARS (Least Angle Regression) algorithm to solve the resulting L1 constrained quadratic optimization problem. Our theoretical results show that our algorithm is guaranteed to converge to the global optimum. Our experiments show that our algorithm significantly outperforms standard algorithms for solving convex optimization problems. Moreover, our algorithm outperforms four previously published algorithms that were specifically designed to solve the L1 regularized logistic regression problem.
Citations
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14 Aug 2017
TL;DR: This thesis proposes a sparse group Lasso (SGL) based approach for linear regression problems with change-points, and extends this method to high dimensional nonhomogeneous linear regression models.
Abstract: Statistical inference plays an increasingly important role in science, finance and industry. Despite the extensive research and wide application of statistical inference, most of the efforts focus on uniform models. This thesis considers the statistical inference in models with abrupt changes instead. The task is to estimate change-points where the underlying models change. We first study low dimensional linear regression problems for which the underlying model undergoes multiple changes. Our goal is to estimate the number and locations of change-points that segment available data into different regions, and further produce sparse and interpretable models for each region. To address challenges of the existing approaches and to produce interpretable models, we propose a sparse group Lasso (SGL) based approach for linear regression problems with change-points. Then we extend our method to high dimensional nonhomogeneous linear regression models. Under certain assumptions and using a properly chosen regularization parameter, we show several desirable properties of the method. We further extend our studies to generalized linear models (GLM) and prove similar results. In practice, change-points inference usually involves high dimensional data, hence it is prone to tackle for distributed learning with feature partitioning data, which implies each machine in the cluster stores a part of the features. One bottleneck for distributed learning is communication. For this implementation concern, we design communication efficient algorithm for feature partitioning data sets to speed up not only change-points inference but also other classes of machine learning problem including Lasso, support vector machine (SVM) and logistic regression.
2 citations
Cites background from "EfficientL 1 regularized logistic r..."
...Again to avoid overfitting and produce sparse results, we usually add a `1 norm penalty as in Lasso to have [5]...
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Proceedings Article•
22 Jul 2007TL;DR: In this article, an efficient interior-point method for solving logistic regression with l1 regularization is proposed, which can solve large sparse problems with up to a thousand or so features and examples in seconds on a PC.
Abstract: Logistic regression with l1 regularization has been proposed as a promising method for feature selection in classification problems Several specialized solution methods have been proposed for l1-regularized logistic regression problems (LRPs) However, existing methods do not scale well to large problems that arise in many practical settings In this paper we describe an efficient interior-point method for solving l1-regularized LRPS Small problems with up to a thousand or so features and examples can be solved in seconds on a PC A variation on the basic method, that uses a preconditioned conjugate gradient method to compute the search step, can solve large sparse problems, with a million features and examples (eg, the 20 Newsgroups data set), in a few tens of minutes, on a PC Numerical experiments show that our method outperforms standard methods for solving convex optimization problems as well as other methods specifically designed for l1- regularized LRPs
2 citations
TL;DR: A logistic regression model with pairwise interactions among a set of binary covariates is considered and it is shown that a simple algorithm that is based on a maximum-weight spanning tree with respect to the plug-in estimates of the influences not only has strong theoretical performance guarantees, but can also outperform generic feature selection algorithms for recovering the interaction graph.
Abstract: An important problem in the field of bioinformatics is to identify interactive effects among profiled variables for outcome prediction. In this paper, a logistic regression model with pairwise interactions among a set of binary covariates is considered. Modeling the structure of the interactions by a graph, our goal is to recover the interaction graph from independently identically distributed (i.i.d.) samples of the covariates and the outcome. When viewed as a feature selection problem, a simple quantity called influence is proposed as a measure of the marginal effects of the interaction terms on the outcome. For the case when the underlying interaction graph is known to be acyclic, it is shown that a simple algorithm that is based on a maximum-weight spanning tree with respect to the plug-in estimates of the influences not only has strong theoretical performance guarantees, but can also outperform generic feature selection algorithms for recovering the interaction graph from i.i.d. samples of the covariates and the outcome. Our results can also be extended to the model that includes both individual effects and pairwise interactions via the help of an auxiliary covariate.
2 citations
Dissertation•
09 Sep 2019
TL;DR: Using a large expression dataset generated under many abiotic stress treatments, many regulatory modules with common regulatory edges were found to be highly co-expressed, suggesting that target modules are structurally stable modules under abioticstress conditions.
Abstract: Abiotic stresses constitute a major category of stresses that negatively impact plant growth and development. It is important to understand how plants cope with environmental stresses and reprogram gene responses which in turn confers stress tolerance. Recent advances of genomic technologies have led to the generation of much genomic data for the model plant, Arabidopsis. To understand gene responses activated by specific external stress signals, these large-scale data sets need to be analyzed to generate new insight of gene functions in stress responses. This poses new computational challenges of mining gene associations and reconstructing regulatory interactions from large-scale data sets. In this dissertation, several computational tools were developed to address the challenges. In Chapter 2, ConSReg was developed to infer condition-specific regulatory interactions and prioritize transcription factors (TFs) that are likely to play condition specific regulatory roles. Comprehensive investigation was performed to optimize the performance of ConSReg and a systematic recovery of nitrogen response TFs was performed to evaluate ConSReg. In Chapter 3, CoReg was developed to infer co-regulation between genes, using only regulatory networks as input. CoReg was compared to other computational methods and the results showed that CoReg outperformed other methods. CoReg was further applied to identified modules in regulatory network generated from DAP-seq (DNA affinity purification sequencing). Using a large expression dataset generated under many abiotic stress treatments, many regulatory modules with common regulatory edges were found to be highly co-expressed, suggesting that target modules are structurally stable modules under abiotic stress conditions. In Chapter 4, exploratory analysis was performed to classify cell types for Arabidopsis root single cell RNA-seq data. This is a first step towards construction of a cell-type-specific regulatory network for Arabidopsis root cells, which is important for improving current understanding of stress response.
2 citations
TL;DR: An efficient iterative training algorithm is developed to learn model parameters of the individual latent GLR mixture model, which combines the coordinate descent approach and the gradient descent approach to minimize the l 2,1 -norm or group regularized logistic loss function.
2 citations
References
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TL;DR: A new method for estimation in linear models called the lasso, which minimizes the residual sum of squares subject to the sum of the absolute value of the coefficients being less than a constant, is proposed.
Abstract: SUMMARY We propose a new method for estimation in linear models. The 'lasso' minimizes the residual sum of squares subject to the sum of the absolute value of the coefficients being less than a constant. Because of the nature of this constraint it tends to produce some coefficients that are exactly 0 and hence gives interpretable models. Our simulation studies suggest that the lasso enjoys some of the favourable properties of both subset selection and ridge regression. It produces interpretable models like subset selection and exhibits the stability of ridge regression. There is also an interesting relationship with recent work in adaptive function estimation by Donoho and Johnstone. The lasso idea is quite general and can be applied in a variety of statistical models: extensions to generalized regression models and tree-based models are briefly described.
40,785 citations
"EfficientL 1 regularized logistic r..." refers methods in this paper
...(Tibshirani 1996) Several algorithms have been developed to solve L1 constrained least squares problems....
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...See, Tibshirani (1996) for details.)...
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...(Tibshirani 1996) Several algorithms have been developed to solve L1 constrained least squares problems....
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Book•
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TL;DR: In this article, the focus is on recognizing convex optimization problems and then finding the most appropriate technique for solving them, and a comprehensive introduction to the subject is given. But the focus of this book is not on the optimization problem itself, but on the problem of finding the appropriate technique to solve it.
Abstract: Convex optimization problems arise frequently in many different fields. A comprehensive introduction to the subject, this book shows in detail how such problems can be solved numerically with great efficiency. The focus is on recognizing convex optimization problems and then finding the most appropriate technique for solving them. The text contains many worked examples and homework exercises and will appeal to students, researchers and practitioners in fields such as engineering, computer science, mathematics, statistics, finance, and economics.
33,341 citations
Book•
01 Jan 1983TL;DR: In this paper, a generalization of the analysis of variance is given for these models using log- likelihoods, illustrated by examples relating to four distributions; the Normal, Binomial (probit analysis, etc.), Poisson (contingency tables), and gamma (variance components).
Abstract: The technique of iterative weighted linear regression can be used to obtain maximum likelihood estimates of the parameters with observations distributed according to some exponential family and systematic effects that can be made linear by a suitable transformation. A generalization of the analysis of variance is given for these models using log- likelihoods. These generalized linear models are illustrated by examples relating to four distributions; the Normal, Binomial (probit analysis, etc.), Poisson (contingency tables) and gamma (variance components).
23,215 citations
01 Jan 1998
12,940 citations
"EfficientL 1 regularized logistic r..." refers methods in this paper
...We tested each algorithm’s performance on 12 different datasets, consisting of 9 UCI datasets (Newman et al. 1998), one artificial dataset called Madelon from the NIPS 2003 workshop on feature extraction,3 and two gene expression datasets (Microarray 1 and 2).4 Table 2 gives details on the number…...
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...We tested each algorithm’s performance on 12 different real datasets, consisting of 9 UCI datasets (Newman et al. 1998) and 3 gene expression datasets (Microarray 1, 2 and 3) 3....
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TL;DR: This is the rst book on generalized linear models written by authors not mostly associated with the biological sciences, and it is thoroughly enjoyable to read.
Abstract: This is the rst book on generalized linear models written by authors not mostly associated with the biological sciences. Subtitled “With Applications in Engineering and the Sciences,” this book’s authors all specialize primarily in engineering statistics. The rst author has produced several recent editions of Walpole, Myers, and Myers (1998), the last reported by Ziegel (1999). The second author has had several editions of Montgomery and Runger (1999), recently reported by Ziegel (2002). All of the authors are renowned experts in modeling. The rst two authors collaborated on a seminal volume in applied modeling (Myers and Montgomery 2002), which had its recent revised edition reported by Ziegel (2002). The last two authors collaborated on the most recent edition of a book on regression analysis (Montgomery, Peck, and Vining (2001), reported by Gray (2002), and the rst author has had multiple editions of his own regression analysis book (Myers 1990), the latest of which was reported by Ziegel (1991). A comparable book with similar objectives and a more speci c focus on logistic regression, Hosmer and Lemeshow (2000), reported by Conklin (2002), presumed a background in regression analysis and began with generalized linear models. The Preface here (p. xi) indicates an identical requirement but nonetheless begins with 100 pages of material on linear and nonlinear regression. Most of this will probably be a review for the readers of the book. Chapter 2, “Linear Regression Model,” begins with 50 pages of familiar material on estimation, inference, and diagnostic checking for multiple regression. The approach is very traditional, including the use of formal hypothesis tests. In industrial settings, use of p values as part of a risk-weighted decision is generally more appropriate. The pedagologic approach includes formulas and demonstrations for computations, although computing by Minitab is eventually illustrated. Less-familiar material on maximum likelihood estimation, scaled residuals, and weighted least squares provides more speci c background for subsequent estimation methods for generalized linear models. This review is not meant to be disparaging. The authors have packed a wealth of useful nuggets for any practitioner in this chapter. It is thoroughly enjoyable to read. Chapter 3, “Nonlinear Regression Models,” is arguably less of a review, because regression analysis courses often give short shrift to nonlinear models. The chapter begins with a great example on the pitfalls of linearizing a nonlinear model for parameter estimation. It continues with the effective balancing of explicit statements concerning the theoretical basis for computations versus the application and demonstration of their use. The details of maximum likelihood estimation are again provided, and weighted and generalized regression estimation are discussed. Chapter 4 is titled “Logistic and Poisson Regression Models.” Logistic regression provides the basic model for generalized linear models. The prior development for weighted regression is used to motivate maximum likelihood estimation for the parameters in the logistic model. The algebraic details are provided. As in the development for linear models, some of the details are pushed into an appendix. In addition to connecting to the foregoing material on regression on several occasions, the authors link their development forward to their following chapter on the entire family of generalized linear models. They discuss score functions, the variance-covariance matrix, Wald inference, likelihood inference, deviance, and overdispersion. Careful explanations are given for the values provided in standard computer software, here PROC LOGISTIC in SAS. The value in having the book begin with familiar regression concepts is clearly realized when the analogies are drawn between overdispersion and nonhomogenous variance, or analysis of deviance and analysis of variance. The authors rely on the similarity of Poisson regression methods to logistic regression methods and mostly present illustrations for Poisson regression. These use PROC GENMOD in SAS. The book does not give any of the SAS code that produces the results. Two of the examples illustrate designed experiments and modeling. They include discussion of subset selection and adjustment for overdispersion. The mathematic level of the presentation is elevated in Chapter 5, “The Family of Generalized Linear Models.” First, the authors unify the two preceding chapters under the exponential distribution. The material on the formal structure for generalized linear models (GLMs), likelihood equations, quasilikelihood, the gamma distribution family, and power functions as links is some of the most advanced material in the book. Most of the computational details are relegated to appendixes. A discussion of residuals returns one to a more practical perspective, and two long examples on gamma distribution applications provide excellent guidance on how to put this material into practice. One example is a contrast to the use of linear regression with a log transformation of the response, and the other is a comparison to the use of a different link function in the previous chapter. Chapter 6 considers generalized estimating equations (GEEs) for longitudinal and analogous studies. The rst half of the chapter presents the methodology, and the second half demonstrates its application through ve different examples. The basis for the general situation is rst established using the case with a normal distribution for the response and an identity link. The importance of the correlation structure is explained, the iterative estimation procedure is shown, and estimation for the scale parameters and the standard errors of the coef cients is discussed. The procedures are then generalized for the exponential family of distributions and quasi-likelihood estimation. Two of the examples are standard repeated-measures illustrations from biostatistical applications, but the last three illustrations are all interesting reworkings of industrial applications. The GEE computations in PROC GENMOD are applied to account for correlations that occur with multiple measurements on the subjects or restrictions to randomizations. The examples show that accounting for correlation structure can result in different conclusions. Chapter 7, “Further Advances and Applications in GLM,” discusses several additional topics. These are experimental designs for GLMs, asymptotic results, analysis of screening experiments, data transformation, modeling for both a process mean and variance, and generalized additive models. The material on experimental designs is more discursive than prescriptive and as a result is also somewhat theoretical. Similar comments apply for the discussion on the quality of the asymptotic results, which wallows a little too much in reports on various simulation studies. The examples on screening and data transformations experiments are again reworkings of analyses of familiar industrial examples and another obvious motivation for the enthusiasm that the authors have developed for using the GLM toolkit. One can hope that subsequent editions will similarly contain new examples that will have caused the authors to expand the material on generalized additive models and other topics in this chapter. Designating myself to review a book that I know I will love to read is one of the rewards of being editor. I read both of the editions of McCullagh and Nelder (1989), which was reviewed by Schuenemeyer (1992). That book was not fun to read. The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities.
10,520 citations
Additional excerpts
...(Nelder & Wedderbum 1972; McCullagh & Nelder 1989)...
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...(Nelder & Wedderbum 1972; McCullagh & Nelder 1989 )...
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