Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
Citations
37 citations
Cites background or methods from "Efflux Pumps of Mycobacterium tuber..."
...Furthermore, other efflux pumps have been described to play a more important role in drug resistance of M. tuberculosis, including the small multidrug-resistant (SMR) pump Rv1218c, the ATP-binding cassette (ABC) transporter Rv2459, and Rv3065 (12–14)....
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...338 339 340 Discussion 341 Co-administration of efflux pump inhibitors with other drugs has been 342 described as a method of improving drug therapies targeting both mammalian 343 and microbial cells (2-5, 24-28), including Mtb (8, 9, 12, 13, 29, 30)....
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...Furthermore, other efflux pumps have been described to play a more 75 important role in drug resistance of Mtb, including the small multidrug resistant 76 (SMR) pump Rv1218c, the ATP-binding cassette (ABC) transporter Rv2459, and 77 Rv3065 (12-14)....
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36 citations
Cites background from "Efflux Pumps of Mycobacterium tuber..."
...There 98 are reported evidences revealing the presence of antibiotic efflux pumps of ABC and SMR 99 family in Mtb (Balganesh et al., 2012)....
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35 citations
Cites background from "Efflux Pumps of Mycobacterium tuber..."
...Well-known transporters from the SMR category include EmrE in E. coli and P. aeruginosa, Smr/Qac in S. aureus and Tbsmr (Rv3065) in M. tuberculosis (Yerushalmi et al. 1995; Brown and Skurray 2001; Li et al. 2003; Balganesh et al. 2012)....
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35 citations
34 citations
References
1,367 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...tuberculosis within its human host, as well (25)....
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1,352 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...Several efflux pumps and their regulators are also induced during macrophage infection (1, 20, 32, 34)....
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1,078 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...No efflux pump inhibitor has yet reached clinical practice, but it is clear that this area of drug development offers a lot of promise, as it will further enhance the effective use of several drugs that have previously been considered to be of great clinical value and also new molecules that are currently under development (24)....
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...This is possible because of the redundancy of their functions, which may overlap extensively (24, 27)....
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979 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...This is possible because of the redundancy of their functions, which may overlap extensively (24, 27)....
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755 citations