Efflux Pumps of Mycobacterium tuberculosis Play a Significant Role in Antituberculosis Activity of Potential Drug Candidates
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329 citations
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Cites background from "Efflux Pumps of Mycobacterium tuber..."
...First, upregulation of three of the known classes of efflux pumps leads to increased MICs of several antibiotics including all first line drugs in vitro (Balganesh et al., 2012; Dinesh et al., 2013)....
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Cites background from "Efflux Pumps of Mycobacterium tuber..."
...Although resistance to TB is multifactorial, the importance of efflux has been identified and documented in a variety of occasions [51, 143]....
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...The list is expanding to include ABC Superfamily members such as DrrAB [52] Bcg0231 (M. bovis BCG) Rv0194 [53] Rv1218c[51] Rv1456c-Rv1457c-Rv1458c [54] and the SMR systems Rv3065 [51] LfrA in M. smegmatis [55] as well as the homologues of M. tuberculosis Rv1145, Rv1146, Rv1877, Rv2846c (efpA), [56] and Rv3065 (mmr and emrE) in both M. tuberculosis and M. smegmatis [57]....
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...bovis BCG) Rv0194 [53] Rv1218c[51] Rv1456c-Rv1457c-Rv1458c [54] and the SMR systems Rv3065 [51] LfrA in M....
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References
176 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...Several investigators are actively involved in the search for such inhibitors (14, 19) to treat various bacterial infections....
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161 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...It could be due to the accumulation of mutations in the target genes over a period of time (21), exclusion of antibiotics by the highly impermeable cell wall (18, 22), the wide array of efflux mechanisms mediated by several ABC (ATP-binding cassette) transporters and major facilitator superfamily (MFS) proteins (9, 10), or antibiotic-modifying and -degrading enzymes (3), to name a few possibilities....
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153 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...Multidrug-resistant (MDR) TB and the highly lethal form called extensively drug-resistant (XDR) TB are adding a new challenge to this old and persistent disease (7, 13)....
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150 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...tuberculosis belonging to different classes have been described in the last few years, and some pumps have been well characterized (2, 6, 8, 11, 29, 30)....
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137 citations
"Efflux Pumps of Mycobacterium tuber..." refers background in this paper
...pAZI0290 Derived from pGOAL19 (15) by deleting...
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...Drug resistance arising out of efflux pump overexpression has been an issue in clinical settings, as well (15, 16, 35), which poses serious problems in the treatment of tuberculosis; this needs to be addressed as a priority....
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