EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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Cites background from "EGF-like growth factors as mediator..."
...Marco Conti and his co-workers showed that LH induces mural granulosa cell expression of epidermal growth factor–like factors that subsequently signal to regulate cumulus expansion-related genes in concert with oocyte-secreted growth factors (for example, GDF9 and BMP15...
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641 citations
Cites background from "EGF-like growth factors as mediator..."
...The effect of these EGF-like factors on cumulus expansion occurs through up-regulation of Ptgs2, Has2, and Tnfaip6 genes (344), whose products are essential for formation and stabilization of the extracellular matrix of the cumulus oophorus....
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...How then does the LH surge lead to induction of target genes in cumulus cells that are critical for cumulus expansion? Conti and colleagues (344) have shown that the LH surge causes a rapid increase in epidermal growth factor (EGF)-like family members, Areg, Ereg, and Btc (encoding amphiregulin, epiregulin, and betacellulin, respectively), specifically in mural granulosa cells of preovulatory follicles....
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...not have an effect on denuded oocytes (344, 441)....
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Cites background from "EGF-like growth factors as mediator..."
...Mural granulosa cells express RNA encoding epidermal growth factor (EGF)-like proteins within 1–3 h after LH receptor stimulation (Park et al. 2004, Ashkenazi et al. 2005), and these proteins, in particular amphiregulin and epiregulin, cause follicle-enclosed as well as cumulusenclosed oocytes to…...
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...Pharmacological inhibition of the EGF receptor in cultured follicles completely inhibits LHinduced oocyte maturation, further supporting a link between these EGF-like proteins and LH (Park et al. 2004)....
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References
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