Journal ArticleDOI
ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Kathryn R. Bowles,M. Catarina Silva,Kristen Whitney,Taylor B. Bertucci,Joshua E. Berlind,Jesse D. Lai,Jesse D. Lai,Jacob C. Garza,Nathan C. Boles,Sidhartha Mahali,Kevin H. Strang,Jacob A. Marsh,Cynthia Chen,Derian A. Pugh,Yiyuan Liu,Ronald E. Gordon,Susan K. Goderie,Rebecca Chowdhury,Steven Lotz,Keith P. Lane,John F. Crary,Stephen J. Haggarty,Celeste M. Karch,Justin K. Ichida,Alison Goate,Sally Temple +25 more
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TLDR
In this article, the authors used human induced pluripotent stem cell (iPSC)-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations because of the mutation that precede neurodegeneration.About:
This article is published in Cell.The article was published on 2021-08-19. It has received 54 citations till now. The article focuses on the topics: Glutamatergic & Neurodegeneration.read more
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Solving neurodegeneration: common mechanisms and strategies for new treatments
Lauren K. Wareham,Shane A. Liddelow,Sally Temple,Larry I. Benowitz,Adriana Di Polo,Cheryl L. Wellington,Jeffrey L. Goldberg,Zhigang He,Xin Duan,Guojun Bu,Albert A. Davis,Karthik Shekhar,Anna La Torre,David C. Chan,M. Valeria Canto-Soler,John G. Flanagan,Preeti Subramanian,Sharyn L. Rossi,Thomas Brunner,Diane E. Bovenkamp,David J. Calkins +20 more
TL;DR: Solving Neurodegeneration as mentioned in this paper is a virtual meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the leading cause of irreversible blindness and the common interest of the three hosting foundations.
Journal ArticleDOI
Solving neurodegeneration: common mechanisms and strategies for new treatments
Lauren K. Wareham,Shane A. Liddelow,Sally Temple,Larry I. Benowitz,Adriana Di Polo,Cheryl L. Wellington,Jeffrey L. Goldberg,Zhigang He,Xin Duan,Guojun Bu,Albert A. Davis,Karthik Shekhar,Anna La Torre,David C. Chan,M. Valeria Canto-Soler,John G. Flanagan,Preeti Subramanian,Sharyn L. Rossi,Thomas Brunner,Diane E. Bovenkamp,David J. Calkins +20 more
TL;DR: Solving Neurodegeneration as discussed by the authors is a virtual meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the leading cause of irreversible blindness and the common interest of the three hosting foundations.
Journal ArticleDOI
Human organoids: New strategies and methods for analyzing human development and disease
TL;DR: A review of advances in organoid biology with a focus on how organoid technology has generated a better understanding of human-specific processes in development and disease can be found in this paper .
Journal ArticleDOI
Human cerebral organoids — a new tool for clinical neurology research
TL;DR: A review of the use of organoid models to accelerate neurological research can be found in this article , where different methodologies for producing organoids and how organoids can be and have been used to model neurological disorders, including microcephaly, Zika virus infection, Alzheimer disease and other neurodegenerative disorders, and neurodevelopmental diseases, such as Timothy syndrome, Angelman syndrome and tuberous sclerosis.
Journal ArticleDOI
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol
Stella M. K. Glasauer,Susan K. Goderie,Jennifer N. Rauch,Elmer Guzman,Morgane Audouard,Taylor B. Bertucci,Shona Joy,Emma Rommelfanger,Gabriel Luna,Erica Keane-Rivera,Steven Lotz,Susan M. Borden,Aaron M. Armando,Oswald Quehenberger,Sally Temple,Kenneth S. Kosik +15 more
TL;DR: The authors found that the cholesterol biosynthesis pathway in astrocytes was the top upregulated gene set compared with isogenic controls by single-cell RNA sequencing (scRNA-seq).
References
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STAR: ultrafast universal RNA-seq aligner
Alexander Dobin,Carrie A. Davis,Felix Schlesinger,Jorg Drenkow,Chris Zaleski,Sonali Jha,Philippe Batut,Mark Chaisson,Thomas R. Gingeras +8 more
TL;DR: The Spliced Transcripts Alignment to a Reference (STAR) software based on a previously undescribed RNA-seq alignment algorithm that uses sequential maximum mappable seed search in uncompressed suffix arrays followed by seed clustering and stitching procedure outperforms other aligners by a factor of >50 in mapping speed.
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featureCounts: an efficient general-purpose program for assigning sequence reads to genomic features
TL;DR: FeatureCounts as discussed by the authors is a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments, which implements highly efficient chromosome hashing and feature blocking techniques.
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Comprehensive Integration of Single-Cell Data.
Tim Stuart,Andrew Butler,Paul J. Hoffman,Christoph Hafemeister,Efthymia Papalexi,William M. Mauck,Yuhan Hao,Marlon Stoeckius,Peter Smibert,Rahul Satija +9 more
TL;DR: A strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities.
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Integrating single-cell transcriptomic data across different conditions, technologies, and species.
TL;DR: An analytical strategy for integrating scRNA-seq data sets based on common sources of variation is introduced, enabling the identification of shared populations across data sets and downstream comparative analysis.
Posted Content
UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction
Leland McInnes,John Healy +1 more
TL;DR: The UMAP algorithm is competitive with t-SNE for visualization quality, and arguably preserves more of the global structure with superior run time performance.
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