Electrospun conductive nanofibrous scaffolds for engineering cardiac tissue and 3D bioactuators.
TL;DR: These conductive nanofibrous sheets performed the ability to enhance cardiomyocytes maturation and spontaneous beating, and further formed 3D bioactuators with tubular and folding shapes, which indicated their great potential in cardiac tissue engineering and bioactUators applications.
About: This article is published in Acta Biomaterialia.The article was published on 2017-09-01. It has received 236 citations till now.
Citations
More filters
TL;DR: This work aims to provide a comprehensive overview of electrospun nanofibers, including the principle, methods, materials, and applications, and highlights the most relevant and recent advances related to the applications by focusing on the most representative examples.
Abstract: Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as "smart" mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.
2,289 citations
TL;DR: The conductive biomaterials used in tissue engineering including conductive composite films, conductive nanofibers, Conductive hydrogels, and Conductive composite scaffolds fabricated by various methods such as electrospinning, coating, or deposition by in situ polymerization are summarized.
515 citations
TL;DR: In vivo experiments indicated that hydrogel with AT addition (OHA-AT/CEC hydrogels) significantly accelerated wound healing rate with higher granulation tissue thickness, collagen disposition and more angiogenesis in a full-thickness skin defect model.
461 citations
15 Nov 2019
TL;DR: The adhesive antibacterial and conductive GT-DA/chitosan/CNT hydrogels showed great potential as multifunctional bioactive dressings for the treatment of infected wounds.
Abstract: Infection is a major obstacle to wound healing. To enhance the healing of infected wounds, dressings with antibacterial activities and multifunctional properties to promote wound healing are highly desirable. Herein, gelatin-grafted-dopamine (GT-DA) and polydopamine-coated carbon nanotubes (CNT-PDA) were used to engineer antibacterial, adhesive, antioxidant and conductive GT-DA/chitosan/CNT composite hydrogels through the oxidative coupling of catechol groups using a H2O2/HRP (horseradish peroxidase) catalytic system. The addition of the antibiotic doxycycline endowed the hydrogels with antimicrobial activity to treat infected full-thickness defect wounds. Additionally, CNT-PDA endowed these hydrogels with an excellent photothermal effect, leading to good in vitro and in vivo antibacterial activities against Gram-positive and Gram-negative bacteria. The catechol group and polydopamine imparted tissue adhesiveness, and the hemostatic and antioxidant abilities of these hydrogels were also investigated. The porosity, degradability, swelling, rheological, mechanical, and conductive behaviors of these hydrogels were finely regulated by changing the concentration of CNT-PDA. Hemolysis and cytocompatibility tests using L929 fibroblast cells confirmed the good biocompatibility of these hydrogels. The wound closure, collagen deposition, histomorphological examination and immunofluorescence staining results demonstrated the excellent effects of these hydrogels in an infected full-thickness mouse skin defect wound. In summary, the adhesive antibacterial and conductive GT-DA/chitosan/CNT hydrogels showed great potential as multifunctional bioactive dressings for the treatment of infected wounds.
383 citations
TL;DR: The presented nanocomposite hydrogels displayed good electrical conductivity, rapid self-healing and adhesive properties, flexible and stretchable mechanical properties, and high sensitivity to near-infrared light and temperature.
Abstract: Self-healing, adhesive conductive hydrogels are of great significance in wearable electronic devices, flexible printable electronics, and tissue engineering scaffolds. However, designing self-healing hydrogels with multifunctional properties such as high conductivity, excellent mechanical property, and high sensitivity remains a challenge. In this work, the conductive self-healing nanocomposite hydrogels based on nanoclay (laponite), multiwalled carbon nanotubes (CNTs), and N-isopropyl acrylamide are presented. The presented nanocomposite hydrogels displayed good electrical conductivity, rapid self-healing and adhesive properties, flexible and stretchable mechanical properties, and high sensitivity to near-infrared light and temperature. These excellent properties of the hydrogels are demonstrated by the three-dimensional (3D) bulky pressure-dependent device, human activity monitoring device, and 3D printed gridding scaffolds. Good cytocompatibility of the conductive hydrogels was also evaluated with L929...
345 citations
References
More filters
01 Jan 2011
5,355 citations
"Electrospun conductive nanofibrous ..." refers background in this paper
...worldwide.[1, 2] The regeneration of damaged heart tissue is severely limited by the poor regenerative potential of myocardium and the scar formation around the infarction sites....
[...]
TL;DR: An overview of electrospinning can be found in this article, where the authors focus on progress achieved in the last three years and highlight some potential applications associated with the remarkable features of electro-spun nanofibers.
Abstract: Electrospinning provides a simple and versatile method for generating ultrathin fibers from a rich variety of materials that include polymers, composites, and ceramics. This article presents an overview of this technique, with focus on progress achieved in the last three years. After a brief description of the setups for electrospinning, we choose to concentrate on the mechanisms and theoretical models that have been developed for electrospinning, as well as the ability to control the diameter, morphology, composition, secondary structure, and spatial alignment of electrospun nanofibers. In addition, we highlight some potential applications associated with the remarkable features of electrospun nanofibers. Our discussion is concluded with some personal perspectives on the future directions in which this wonderful technique could be pursued.
5,117 citations
"Electrospun conductive nanofibrous ..." refers background or methods in this paper
...16 distance, and temperature would contribute to the diameter of nanofibers.[31-34] Previous studies have demonstrated that the addition of conductive materials such carbon nanotubes (CNT) and PANI within electrospun solution could decrease the...
[...]
...[24, 27-30] Among these approaches, electrospinning has been regarded as a simple and versatile method to prepare nanofibrous scaffolds, and also allowed for the manipulation of many parameters, including fiber diameter, fiber orientation and fiber density.[31-37] Due to the similarity between nanofibrous structure and...
[...]
TL;DR: More than 20 polymers, including polyethylene oxide, nylon, polyimide, DNA, polyaramid, and polyaniline, have been electrospun in this paper.
Abstract: Electrospinning uses electrical forces to produce polymer fibres with nanometre-scale diameters. Electrospinning occurs when the electrical forces at the surface of a polymer solution or melt overcome the surface tension and cause an electrically charged jet to be ejected. When the jet dries or solidifies, an electrically charged fibre remains. This charged fibre can be directed or accelerated by electrical forces and then collected in sheets or other useful geometrical forms. More than 20 polymers, including polyethylene oxide, nylon, polyimide, DNA, polyaramid, and polyaniline, have been electrospun in our laboratory. Most were spun from solution, although spinning from the melt in vacuum and air was also demonstrated. Electrospinning from polymer melts in a vacuum is advantageous because higher fields and higher temperatures can be used than in air.
3,431 citations
"Electrospun conductive nanofibrous ..." refers background or methods in this paper
...16 distance, and temperature would contribute to the diameter of nanofibers.[31-34] Previous studies have demonstrated that the addition of conductive materials such carbon nanotubes (CNT) and PANI within electrospun solution could decrease the...
[...]
...[24, 27-30] Among these approaches, electrospinning has been regarded as a simple and versatile method to prepare nanofibrous scaffolds, and also allowed for the manipulation of many parameters, including fiber diameter, fiber orientation and fiber density.[31-37] Due to the similarity between nanofibrous structure and...
[...]
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
Abstract: It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
2,804 citations
"Electrospun conductive nanofibrous ..." refers background in this paper
...[1, 2] The regeneration of damaged heart tissue is severely limited by the poor regenerative potential of myocardium and the scar formation around the infarction sites.[3, 4] Tissue engineering is a promising approach for cardiac regeneration by combining biomaterials and cardiomyocytes (CMs) to generate engineered cardiac tissue constructs, and also has potential application for fabricating...
[...]
TL;DR: Key features of the epidemiology and risk profile of HF are discussed, including ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, that both predict the incidence of HF as well as its severity.
Abstract: Heart failure (HF) is a major public health issue, with a prevalence of over 5.8 million in the USA, and over 23 million worldwide, and rising. The lifetime risk of developing HF is one in five. Although promising evidence shows that the age-adjusted incidence of HF may have plateaued, HF still carries substantial morbidity and mortality, with 5-year mortality that rival those of many cancers. HF represents a considerable burden to the health-care system, responsible for costs of more than $39 billion annually in the USA alone, and high rates of hospitalizations, readmissions, and outpatient visits. HF is not a single entity, but a clinical syndrome that may have different characteristics depending on age, sex, race or ethnicity, left ventricular ejection fraction (LVEF) status, and HF etiology. Furthermore, pathophysiological differences are observed among patients diagnosed with HF and reduced LVEF compared with HF and preserved LVEF, which are beginning to be better appreciated in epidemiological studies. A number of risk factors, such as ischemic heart disease, hypertension, smoking, obesity, and diabetes, among others, have been identified that both predict the incidence of HF as well as its severity. In this Review, we discuss key features of the epidemiology and risk profile of HF.
1,718 citations
"Electrospun conductive nanofibrous ..." refers background in this paper
...worldwide.[1, 2] The regeneration of damaged heart tissue is severely limited by the poor regenerative potential of myocardium and the scar formation around the infarction sites....
[...]