Journal ArticleDOI
Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts
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In this article, composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems.Abstract:
Composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems. The precursor solution of 10 mL PVP 10% w/w and GME 2% w/w was then electrospun collected at the rotating collector at the following optimum parameters: a voltage of 15 kV, a collector-nozzle distance of 12 cm, and a flow rate of 1 mL/hour. SEM images showed that the average diameters were 476 nm and 690 nm for the PVP and PVP-GME composite nanofibers, respectively. To some degree, the addition of GME into PVP nanofibers increased the average diameter size of nanofibers. Moreover, the release studies, it was shown that 80% of the GME was released within 30 minutes. Therefore, the PVP-GME composite nanofibers can be applied as the drug delivery systems.read more
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Journal ArticleDOI
The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review
Paola Franco,Iolanda De Marco +1 more
TL;DR: This review highlights the role of PVP in drug delivery, focusing on the different morphologies proposed for different polymer/active compound formulations, and provides detailed information on active principles and used technologies, optimized process parameters, advantages, disadvantages, and final applications.
Journal ArticleDOI
Fast dissolving drug delivery membrane based on the ultra-thin shell of electrospun core-shell nanofibers
TL;DR: The present investigation paved a new way for implementing the modified coaxial processes, which can be utilized to fabricate structural nanocomposites with ultra‐thin shells for enhancing the fast dissolution of poorly water‐soluble drugs.
Journal ArticleDOI
Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning
Ida Sriyanti,Dhewa Edikresnha,Annisa Rahma,Muhammad Miftahul Munir,Heni Rachmawati,Khairurrijal Khairurrijal +5 more
TL;DR: In this paper, a conformational change in the C-H chain of polyvinyl(pyrrolidone) occurred in the composite nanofiber mat due to the intermolecular interactions.
Journal ArticleDOI
Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α-mangostin.
Ida Sriyanti,Dhewa Edikresnha,Annisa Rahma,Muhammad Miftahul Munir,Heni Rachmawati,Khairurrijal Khairurrijal +5 more
TL;DR: A promising approach to improve the clinical use of α-mangostin through electrospinning technique is reported, with enhanced antioxidant activity and release rate, which can potentially improve the therapeutic effects offered by MPE.
Journal ArticleDOI
Electrospun metronidazole-loaded nanofibers for vaginal drug delivery.
TL;DR: Vaginal use of metronidazole-loaded nanofibers has been shown to be a potential drug delivery system for the treatment of BV.