Elementary and global aspects of calcium signalling.
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5,369 citations
Cites background from "Elementary and global aspects of ca..."
...Further versatility is achieved by varying the spatial and temporal aspects of Ca 2+ signallin...
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2,059 citations
Cites background from "Elementary and global aspects of ca..."
...The existence of such Ca21events (Bootman and Berridge 1995; Berridge, 1997; waves is very dependent on the progressive loading ofLipp and Niggli, 1997)....
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...…the subsurfacein cardiac cells, in that Ca21 entering through voltage- operated channels triggers RYR2s to release internal cisternae have much in common with the triadic junctions in muscle and may thus be responsible for theCa21 through a process of Ca21-induced Ca21 release (Berridge, 1997)....
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"Elementary and global aspects of ca..." refers background in this paper
...In order to overcome the twin problems of an inherent cytotoxicity and low diffusibility, cells have evolved an ingenious mechanism of signalling based on presenting Ca2+ as brief spikes often organized as regenerative waves (Cheek, 1991; Berridge, 1993; Clapham, 1995)....
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...In most cells, it is the internal stores which provide most of the signal Ca2+ so attention has focused on the intracellular Ca2+ channels, of which there are two main types (Berridge, 1993; Clapham, 1995)....
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...In most cells, it is the internal stores which provide most of the signal Ca 2+ so attention has focused on the intracellular Ca 2+ channels, of which there are two main types (Berridge, 1993; Clapham, 1995)....
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"Elementary and global aspects of ca..." refers background in this paper
...Ca2+ imaging has revealed that these units can fire spontaneously and independently of each other to produce sparks which fail to activate neighbouring units because of their low Ca2+ sensitivities (Cheng et al. 1993; Lopez-Lopez et al. 1995; Cannell et al. 1995)....
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...The brief opening of these channels gives rise to localized pulses (approximately 2 µm in diameter) such as the sparks in cardiac muscle (Cheng et al. 1993) or the blips and puffs in Xenopus oocytes (Yao et al. 1995; Parker and Yao, 1996)....
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...In effect, this Ca2+ overload converts the cytoplasm into an excitable medium such that a Ca2+ spark can ignite neighbouring units, thereby setting up a regenerative Ca2+ wave (Cheng et al. 1993)....
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