Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
Thomas Greither,Lukasz F. Grochola,Andrej Udelnow,Christine Lautenschläger,Peter Würl,Helge Taubert +5 more
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TLDR
This study provides the first evidence for an oncogenic activity ofmiR‐155, miR‐203, miM‐210 and miR-222 in the development of pancreatic cancer as has been reported for other tumor types.Abstract:
Pancreatic cancer is the eighth most common cancer and has an overall 5-year survival rate lower than 10%. Because of their ability to regulate gene expression, microRNAs can act as oncogenes or tumor-suppressor genes and so have garnered interest as possible prognostic and therapeutic markers during the last decade. However, the prognostic value of microRNA expression in pancreatic cancer has not been thoroughly investigated. We measured the levels of miR-155, miR-203, miR-210, miR-216, miR-217 and miR-222 by quantitative RT-PCR in a cohort of 56 microdissected pancreatic ductal adenocarcinomas (PDAC). These microRNAs were chosen as they had previously been shown to be differentially expressed in pancreatic tumors compared to normal tissues. The possible association of microRNA expression and patients' survival was examined using multivariate Cox's regression hazard analyses. Interestingly, significant correlations between elevated microRNA expression and overall survival were observed for miR-155 (RR = 2.50; p = 0.005), miR-203 (RR = 2.21; p = 0.017), miR-210 (RR = 2.48; p = 0.005) and miR-222 (RR = 2.05; p = 0.035). Furthermore, tumors from patients demonstrating elevated expression levels of all 4 microRNAs possessed a 6.2-fold increased risk of tumor-related death compared to patients whose tumors showed a lower expression of these microRNAs. This study provides the first evidence for an oncogenic activity of miR-155, miR-203, miR-210 and miR-222 in the development of pancreatic cancer as has been reported for other tumor types. Furthermore, the putative target genes for these microRNAs suggest a complex signaling network that can affect PDAC tumorigenesis and tumor progression.read more
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MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene
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MicroRNAs in NF-κB signaling
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MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy
TL;DR: This review summarizes the most significant and latest findings of original researches on micro RNAs involvement in cancer, focusing on the potential of cancer-related microRNAs as biomarkers for diagnosis, prognosis and targets for therapy.
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Effect of exosomal miRNA on cancer biology and clinical applications.
Zhenqiang Sun,Ke Shi,Shuaixi Yang,Jinbo Liu,Quanbo Zhou,Guixian Wang,Junmin Song,Zhen Li,Zhiyong Zhang,Weitang Yuan +9 more
TL;DR: The intercommunication occurring between different cells via exosomal miRNAs in tumor microenvironmnt is described, with impacts on tumor proliferation, vascularization, metastasis and other biological characteristics.
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