Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.
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...NETs are also present in the carotid lumen in ApoE-deficient mice on high-fat diet, proximal to atherosclerotic lesions,(56) supporting the clinical observation that NETs are implicated in coronary atherosclerosis.(57)...
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...In coronary artery disease,MPO-DNA complexes are elevated in the more severe cases, positively associatedwith elevated thrombin levels, and robustly predict adverse cardiac events.(57) DNA, nucleosome, and MPO levels correlate with disease state in patients with thrombotic microangiopathies (TMAs), including thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome, and malignant tumorinduced TMA....
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...histones and azurophilic granule proteins, such as MPO and PMN elastase.(4) Histone degradation and citrullination, driven by PMN elastase and peptidylarginine deiminase 4, respectively, are key processes, which comprise the cornerstone of chromatin decondensation and subsequent NET formation....
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...histones and granule proteins, are cast out, providing an extracellular scaffold to trap and kill microbial pathogens.(4) There...
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...Nucleosomes and histones can promote thrombin formation through the activation of either extrinsic or intrinsic coagulation pathways and through platelet activation.(7,12,35,40,41) In addition, excess of extracellular histones can affect the function of the anticoagulant protein C pathway by inhibiting protein C activation, thus resulting in enhanced thrombin formation....
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