Elimination of testicular regression by 12-hr temporal relationship of serotonergic and dopaminergic activity in Indian palm squirrel, Funambulus pennanti.

doi:10.1007/BF01249108

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Elimination of testicular regression by 12-hr temporal relationship of serotonergic and dopaminergic activity in Indian palm squirrel, Funambulus pennanti.

Journal Article•DOI•

Elimination of testicular regression by 12-hr temporal relationship of serotonergic and dopaminergic activity in Indian palm squirrel, Funambulus pennanti.

Ranjana Jaiwal¹, Chandra Mohini Chaturvedi¹•Institutions (1)

Banaras Hindu University¹

01 Jan 1991-Journal of Neural Transmission (J Neural Transm Gen Sect)-Vol. 84, Iss: 1, pp 45-52

TL;DR: It is concluded that specific phase relation (12-hr) between circadian serotonergic and dopaminergic oscillations may induce breeding condition in regressing gonad of Indian Palm Squirrel during post-reproductive phase of annual gonadal cycle.

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Abstract: Specific temporal relationship (12-hr) of serotonin and dopamine activity was induced by precursor drugs (5-HTP and L-DOPA) in Indian Palm SquirrelFunambulus pennanti during testicular regression phase. This treatment established breeding condition unlike control, which experienced complete atrophy of testes and accessory sex organs.

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Journal Article•DOI•

Temporal phase relation of circadian neural oscillations alters RFamide-related peptide-3 and testicular function in the mouse.

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Sumit Sethi¹, Kazuyoshi Tsutsui, Chandra Mohini Chaturvedi¹•Institutions (1)

Banaras Hindu University¹

01 Jan 2010-Neuroendocrinology

TL;DR: Findings not only suggest the modulation of gonadal development in mice by changing the temporal phase relation of serotonergic and dopaminergic oscillations, but also demonstrate an inverse correlation of RFRP-3 neurons and gonadal activity in both control and experimental conditions.

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Abstract: In order to study the effect of the temporal synergism of neural oscillations on reproductive regulation and the response of RFamide-related peptide-3 (RFRP-3; a mammalian ortholog of avian gonadotropin-inhibitory hormone), expression of immunoreactive RFRP-3 in the neurons of the dorsomedial nucleus of the hypothalamus was monitored in sexually immature and mature laboratory mice (study I). In study II, the effects of serotonin and dopamine precursors (5-hydroxytryptophan and L-dihydroxyphenylalanine; injected daily, 8 or 12 h apart, for 13 days in 3-week-old mice) on testicular activity and immunoreactive RFRP-3 neurons were studied until 24 days after treatment. Results indicate high levels of expression of immunoreactive RFRP-3 in the sexually immature and 8-hour mice (simulating gonadal suppression), while a low level was noted in mature and 12-hour mice (simulating gonadal stimulation). These findings not only suggest the modulation of gonadal development in mice (during the course of puberty attainment) by changing the temporal phase relation of serotonergic and dopaminergic oscillations (as in some seasonally breeding species), but also demonstrate an inverse correlation of RFRP-3 neurons and gonadal activity in both control and experimental conditions.

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23 citations

Cites background from "Elimination of testicular regressio..."

...On the other hand, if these drugs are injected 8 h apart (8- hour relation), this may lead to gonadal suppression/non-breeding conditions, while other relations (0, 4, 16 and 20 h) have been found to be ineffective. In the Indian palm squirrel, Funambulus pennantii , the 12-hour phase relation of serotonergic and dopaminergic oscillations not only extends the breeding season, but may also eliminate annual reproductive regression [...
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Journal Article•DOI•

Temporal synergism of neurotransmitters (serotonin and dopamine) affects testicular development in mice.

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Sumit Sethi¹, Chandra Mohini Chaturvedi¹•Institutions (1)

Banaras Hindu University¹

01 Nov 2009-Zoology

TL;DR: It is concluded that normal somatic and gonadal growth of pre-puberal mice may be suppressed with an 8-hr phase relation of circadian serotonergic and dopaminergic oscillations, which accelerated the rate of gonadal maturation and led to more or less similar gonadal development as in the control mice.

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19 citations

Journal Article•DOI•

Age-dependent variation in the RFRP-3 neurons is inversely correlated with gonadal activity of mice

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Sumit Sethi¹, Kazuyoshi Tsutsui², Chandra Mohini Chaturvedi¹•Institutions (2)

Banaras Hindu University¹, Waseda University²

15 Sep 2010-General and Comparative Endocrinology

TL;DR: The present findings indicate that hyperactivity of the ir-RFRP-3 neurons of dorsomedial nucleus of hypothalamus (DMH) observed in prepubertal mice declines in reproductively active mice and increases again in the old mice having declined reproductive performance.

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17 citations

Cites methods from "Elimination of testicular regressio..."

...The length and width of the left testis was measured in situ with dial calipers, and the testicular volume was calculated using Bissonett’s formula 4/3pab(2) (a = 1/2 of the long axis; b = 1/2 of the short axis) (Jaiwal and Chaturvedi, 1991)....
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...The length and width of the left testis was measured in situ with dial calipers, and the testicular volume was calculated using Bissonett’s formula 4/3pab2 (a = 1/2 of the long axis; b = 1/2 of the short axis) (Jaiwal and Chaturvedi, 1991)....
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Journal Article•DOI•

Reproductive phase dependent circadian variation in hypothalamic concentration of serotonin, dopamine and peripheral thyroxine levels in Japanese Quail following 5-HTP and L-DOPA administration at specific time intervals

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A. C. Tiwari¹, Praveen Kumar¹, Satya Pratap Singh¹, Dharmendra Sharma¹, Chandra Mohini Chaturvedi¹ - Show less +1 more•Institutions (1)

Banaras Hindu University¹

21 Aug 2006-Biological Rhythm Research

TL;DR: The findings suggest that the temporal phase relation of circadian serotonergic and dopaminergic oscillator varies as a function of reproductive status of the bird, and breeding/non-breeding conditions may be induced experimentally by changing the phase relationof these oscillations.

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Abstract: Temporal phase relations of circadian hypothalamic neurotransmitters are reported to regulate seasonal reproduction in some avian species. Present experiments were designed to study circadian variation in the hypothalamic concentration of neurotransmitters (serotonin and dopamine) and the plasma thyroxine level in sexually active (long day) and inactive (short day) Japanese Quail. A significant circadian cycle was noted in the hypothalamic content of both serotonin and dopamine, but with different patterns. In breeding Quail, peak activity of serotonin and dopamine was noted at 10.00 A.M. and 10.00 P.M. respectively i.e. at the interval of 12 hours. However, during sexually quiescent condition, peaks of both neurotransmitters occurred at 2.00 P.M. i.e. having a 0-hour temporal relationship. During the breeding phase, the plasma thyroxine level showed a biphasic pattern with two circadian peaks at 10.00 A.M. and 10.00 P.M. whereas in the non-breeding condition a single peak was observed at 10.00 A...

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16 citations

Journal Article•DOI•

Suppression of annual testicular development in Indian Palm Squirrel, Funambulus pennanti by 8 hr temporal relationship of serotonin and dopamine precursor drugs

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Chandra Mohini Chaturvedi¹, A. B. Singh•Institutions (1)

Banaras Hindu University¹

01 Jan 1992-Journal of Neural Transmission

TL;DR: Results indicate that induced suppression of gonadal function in a fashion similar to seasonal regression leading to non-breeding condition is the consequence of specific phase relationship (8 hr) between serotonergic and dopaminergic activities and not due to Serotonin or dopamine alone.

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Abstract: Daily injections of 5-HTP (5-hydroxytryptophan, serotonin precursor) and L-DOPA (L-Dihydroxyphenylalanine, dopamine precursor) given 8 hour apart inhibited normal testicular growth in seasonally breeding Indian Palm Squirrel,Funambuluspennanti leading to complete gonadal atrophy, which was maintained till the end of the study. HCG administration induced higher degree of gonadal development but, when the two treatments (HCG + 8 hr relationship of 5-HTP and L-DOPA) were given simultaneously no significant difference was observed compared to control.

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13 citations

Cites background from "Elimination of testicular regressio..."

...Second study in this series reported that L-DOPA injected 12 hr after 5-HTP may even induce redevelopment of gonad up to full breeding condition when given in sexually quiescent phase of annual cycle (Jaiwal and Chaturvedi, 1991)....
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..., when two drugs were given 8 hr apart non-breeding condition was induced (present study) but when given 12hr apart breeding condition was established (Chaturvedi and Jaiwal, 1990; Jaiwal and Chaturvedi, 1991)....
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References

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Journal Article•DOI•

Temporal synergism of neurotransmitter affecting drugs and seasonal reproductive responses of Indian Palm Squirrel, Funambulus pennanti.

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Chandra Mohini Chaturvedi¹, Ranjana Jaiwal¹•Institutions (1)

Banaras Hindu University¹

01 Jan 1990-Journal of Neural Transmission

TL;DR: It is suggested that response in the present study is not a pharmacological effect of drugs but temporal synergism of neural acitivities affected the seasonality of reproduction as only 12-hour-relation of 5-HTP and L-DOPA maintained breeding activity during post reproductive phase of annual gonad cycle in Palm Squirrel.

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Abstract: Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 12 hour after 5-hydroxytryptophan (5-HTP, serotonin precursor) eliminated annual testicular regression in seasonally breeding sub-tropical Palm Squirrel that undergoes seasonal changes in responsiveness to day-length and humidity. Other temporal relations (L-DOPA given 0, 4, 8, 16 and 20 hours after 5-HTP administration) decreased/delayed the rate of regression and maintained the reproductive system at intermediate level. 12-hour-relation maintained full breeding condition (maximum gonad and accessory sex organs) unlike control, which exhibited complete atrophy of primary and accessory sex organs.

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19 citations

"Elimination of testicular regressio..." refers background or methods in this paper

...In the earlier report of this series (Chaturvedi and Jaiwal, 1990) it was found that 12-hr relation of serotonergic and dopaminergic drugs did not allow the annual regression (which starts in August) and gonad were maintained continuously in breeding condition till September when experiment was terminated....
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...83~ in the month of July and acclimatized for two weeks in Laboratory condition (Chaturvedi and Jaiwal, 1990)....
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...To test the validity of this hypothesis in subtropical species a preliminary experiment (Chaturvedi and Jaiwal, 1990) was performed in Indian Palm Squirrel....
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...But, only 12hr relation altered the seasonality and maintained continuous breeding condition eliminating seasonal gonadal regression (Chaturvedi and Jaiwal, 1990)....
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Journal Article•DOI•

Effect of pinealectomy on photoperiodic gonadal response of Indian palm squirrel, Funambulus pennanti

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C. Haldar-Misra, M. Srivastava

01 Apr 1987-Canadian Journal of Zoology

TL;DR: The role of the pineal gland in mediating the effects of photoperiod on the reproductive axis is not well established in tropical mammals, but when Indian palm squirrels (Funambulus pennanti) were exposed to sunlight, they showed marked changes in their sexual behaviour.

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Abstract: The role of the pineal gland in mediating the effects of photoperiod on the reproductive axis is not well established in tropical mammals. Indian palm squirrels (Funambulus pennanti) were exposed t...

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12 citations