Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies.
Sepideh Mirzaei,Kiavash Hushmandi,Amirhossein Zabolian,Hossein Saleki,Seyed Mohammad Reza Torabi,Adnan Ranjbar,SeyedHesam SeyedSaleh,Seyed Omid Sharifzadeh,Haroon Khan,Milad Ashrafizadeh,Ali Zarrabi,Kwang Seok Ahn +11 more
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TLDR
Wang et al. as mentioned in this paper discussed the association of ROS with Cisplatin sensitivity/resistance, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy, and anti-tumor compounds such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described.Abstract:
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective treatment of cancer patients, it is of great importance to reveal the molecular pathways and mechanisms involved in chemoresistance. Cisplatin (CP) is a platinum-containing drug with anti-tumor activity against different cancers in both pre-clinical and clinical studies. However, drug resistance has restricted its potential in the treatment of cancer patients. CP can promote levels of free radicals, particularly reactive oxygen species (ROS) to induce cell death. Due to the double-edged sword role of ROS in cancer as a pro-survival or pro-death mechanism, ROS can result in CP resistance. In the present review, association of ROS with CP sensitivity/resistance is discussed, and in particular, how molecular pathways, both upstream and downstream targets, can affect the response of cancer cells to CP chemotherapy. Furthermore, anti-tumor compounds, such as curcumin, emodin, chloroquine that regulate ROS and related molecular pathways in increasing CP sensitivity are described. Nanoparticles can provide co-delivery of CP with anti-tumor agents and by mediating photodynamic therapy, and induce ROS overgeneration to trigger CP sensitivity. Genetic tools, such as small interfering RNA (siRNA) can down-regulate molecular pathways such as HIF-1α and Nrf2 to promote ROS levels, leading to CP sensitivity. Considering the relationship between ROS and CP chemotherapy, and translating these findings to clinic can pave the way for effective treatment of cancer patients.read more
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Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression
Milad Ashrafizadeh,Sepideh Mirzaei,Mohammad Hossein Gholami,Farid Hashemi,Amirhossein Zabolian,Mehdi Raei,Kiavash Hushmandi,Ali Zarrabi,Nicolas H. Voelcker,Amir Reza Aref,Michael R. Hamblin,Rajender S. Varma,Saeed Samarghandian,I.J. Arostegi,M. Alzola,Alan Prem Kumar,Vijay Kumar Thakur,Noushin Nabavi,Pooyan Makvandi,Franklin R. Tay,Gorka Orive +20 more
TL;DR: Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance.
Journal ArticleDOI
Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer.
Sepideh Mirzaei,Mohammad Hossein Gholami,Amirhossein Zabolian,Hossein Saleki,Mahdi Vasheghani Farahani,Soodeh Hamzehlou,Fatemeh Bakhtiari Far,Seyed Omid Sharifzadeh,Saeed Samarghandian,Haroon Khan,Amir Reza Aref,Milad Ashrafizadeh,Ali Zarrabi,Gautam Sethi +13 more
TL;DR: In this article, a review of the potential of CA and its derivatives in cancer therapy is presented, with a focus on molecular pathways to pave the way for rapid translation of CA for clinical use.
Journal ArticleDOI
Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects
Asal Jalal Abadi,Sepideh Mirzaei,Mahmood Khaksary Mahabady,Farid Hashemi,Amirhossein Zabolian,Fardin Hashemi,Pourya Raee,Shahin Aghamiri,Milad Ashrafizadeh,Amir Reza Aref,Michael R. Hamblin,Michael R. Hamblin,Kiavash Hushmandi,Ali Zarrabi,Gautam Sethi +14 more
TL;DR: Curcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies as discussed by the authors.
Journal ArticleDOI
Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways.
TL;DR: In this article, the role of Wnt signaling in hepatocellular carcinoma (HCC) and its association with progression and therapy response based on pre-clinical and clinical evidence is discussed.
References
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