Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Journal ArticleDOI
Muscle Excursion Does Not Correlate with Increased Serial Sarcomere Number after Muscle Adaptation to Stretched Tendon Transfer
TL;DR: These data are the first to report that muscle morphological adaptation after chronic stretch does not accurately predict the muscle's functional properties, and have significant implications for examining muscle physiological properties under surgical interventions.
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Efficiency of skeletal muscle decellularization methods and their effects on the extracellular matrix.
TL;DR: The results suggest that latrunculin B is the most efficient method for decellularizing skeletal muscle and that the remaining ECM accounts for approximately half of the stiffness in passive muscle.
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A 3D, Magnetically Actuated, Aligned Collagen Fiber Hydrogel Platform Recapitulates Physical Microenvironment of Myoblasts for Enhancing Myogenesis
Nianyuan Shi,Yuhui Li,Le Chang,Guoxu Zhao,Guorui Jin,Yi Lyu,Guy M. Genin,Guy M. Genin,Yufei Ma,Feng Xu +9 more
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Increase of resting muscle stiffness, a less considered component of age-related skeletal muscle impairment.
Lorenzo Marcucci,Carlo Reggiani +1 more
TL;DR: This short review discusses the possible determinants of the limitations of joint mobility in healthy elderly, starting with the age-dependent alterations of the articular structure and focusing on the increased stiffness of the skeletal muscles.
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Age-associated changes in the mechanical properties of human cadaveric pelvic floor muscles.
Lindsey A. Burnett,Mark S. Cook,Sameer B. Shah,Michelle Wong,Deborah M. Kado,Marianna Alperin +5 more
TL;DR: Age-associated increase in PFM stiffness is predicted to negatively impact PFM function by diminishing muscle load-bearing, excursional, contractile, and regenerative capacity, thus predisposing older women to PFDs.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.