Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
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The Effect of the Wooden Breast Fibrotic Myopathy in Broilers on Fibrillar Collagen Organization and Decorin-Collagen Binding.
TL;DR: Key findings from the study showed that collagen shifts to larger diameter collagen fibril bundles with the wooden breast myopathy, providing further evidence that multiple fibrotic myopathies are likely in fast-growing meat-type broilers.
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Investigating the passive mechanical behaviour of skeletal muscle fibres: Micromechanical experiments and Bayesian hierarchical modelling
TL;DR: The mechanical properties of skeletal muscle fibres under axial tension, axial compression, and transversal compression are examined for the first time, leading to a highly comprehensive data set and a Bayesian hierarchical modelling concept to identify model parameters in a broad way.
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Characterization of the passive mechanical properties of spine muscles across species.
TL;DR: The primary objective was to determine the parameters required to simulate the passive force-length relationship and to hypothesized that multifidus, believed to specialize in spine stabilization, would generate greater passive tensile stresses under isometric conditions than erector spinae, which have more generalized functions of moving and stabilizing the spine.
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Investigating Passive Muscle Mechanics With Biaxial Stretch.
TL;DR: This work developed and employed a constitutive model of passive skeletal muscle that includes aligned muscle fibers and dispersed ECM collagen fibers with a bimodal von Mises distribution and uses constitutive modeling and finite element analysis to explore the interaction between stiffness, constituent variability, and applied deformation in passive muscle stiffness.
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Modeling Skeletal Muscle Stress and Intramuscular Pressure: A Whole Muscle Active-Passive Approach.
TL;DR: A finite element model of whole skeletal muscle that can predict IMP under passive and active conditions is developed to further investigate the mechanisms of IMP variability and may explain variability of in vivo IMP measurements in the clinic.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.