Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Structural and functional characteristics of the thoracolumbar multifidus muscle in horses.
J. A. García Liñeiro,Guillermo H. Graziotti,J. M. Rodríguez Menéndez,C. M. Ríos,N. O. Affricano,C. Victorica +5 more
TL;DR: It can be concluded that the equine multifidus muscle in horses is an immunohistochemically homogeneous muscle with various architectural designs that have functional significance according to the vertebral motion segments considered.
Journal ArticleDOI
Ultrasound Shear Wave Elastography for Evaluation of Diaphragm Stiffness in Patients with Stable COPD: A Pilot Trial.
Jing-Hong Xu,Zhen-Zhou Wu,Fang-Yi Tao,Shu-Ting Zhu,Shun-Ping Chen,Chang Cai,Zeng-Hui Liang,Bin-Bin Shi,Bin Chen,Yu-Peng Xie +9 more
TL;DR: In this article, the diaphragmatic stiffness was measured via ultrasound shear wave velocity (SWV) at functional residual capacity (FRC), which was associated with the forced expiratory volume in one second.
Journal ArticleDOI
Structure-function relationship of the human external anal sphincter.
Amanda M. Stewart,Mark S. Cook,Keisha Y. Dyer,Keisha Y. Dyer,Marianna Alperin,Marianna Alperin +5 more
TL;DR: This first direct examination of human EAS underscores how EAS intrinsic design matches its intended function as well as investigating whether vaginal delivery alters the EAS structure–function relationship.
Journal ArticleDOI
In vivo human gracilis whole-muscle passive stress-sarcomere strain relationship.
Lomas S. Persad,Benjamin I. Binder-Markey,Alexander Y. Shin,Kenton R. Kaufman,Richard L. Lieber,Richard L. Lieber +5 more
TL;DR: In this paper, the authors measured the passive mechanical properties of intact, living human gracilis muscles (n=11 individuals, 10 male and 1 female, age: 33±12 years, mass: 89±23 kg, height: 177±8 cm).
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Fiber Type and Size as Sources of Variation in Human Single Muscle Fiber Passive Elasticity
Alex M. Noonan,Derek P. Zwambag,Nicole Mazara,Erin Weersink,Geoffrey A. Power,Stephen H.M. Brown +5 more
TL;DR: This study was designed to determine if the elastic modulus is inherently different between type 1 and type 2 muscle fibres, and whether stiffness was linearly related to fibre cross-sectional area, as would be expected for a homogenous material.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
Journal ArticleDOI
Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.