Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Skeletal muscle mechanics, energetics and plasticity
Richard L. Lieber,Richard L. Lieber,Thomas J. Roberts,Silvia S. Blemker,Sabrina S.M. Lee,Walter Herzog +5 more
TL;DR: A vast array of basic and clinical problems in skeletal muscle mechanics and physiology, with some solutions, and many suggestions for future research are treated.
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On the anisotropy of skeletal muscle tissue under compression.
TL;DR: Results provide experimental evidence that there is an anisotropic contribution of the fibre direction to the compressive stress in muscle fibres when muscle tissue is subjected to compressive loads.
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Skeletal muscle fibroblasts in health and disease.
TL;DR: The role that fibroblasts and other cells play in muscle fibrosis is discussed, which is a devastating clinical condition characterized by an overproduction of ECM within skeletal muscle.
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Functional analysis of limb recovery following autograft treatment of volumetric muscle loss in the quadriceps femoris.
Mon Tzu Alice Li,Mon Tzu Alice Li,Nick J. Willett,Nick J. Willett,Brent A. Uhrig,Brent A. Uhrig,Robert E. Guldberg,Robert E. Guldberg,Gordon L. Warren +8 more
TL;DR: This new model with quantitative functional outcome measures offers a platform on which to evaluate treatment strategies designed to regenerate muscle tissue volume and restore limb function, consistent with clinical findings of reduced muscle function in large VML injuries.
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Impact of vaginal parity and aging on the architectural design of pelvic floor muscles
TL;DR: Increased fiber length in more proximal pelvic floor muscles likely represents an adaptive response to the chronically increased load placed on these muscles by the displaced apical structures, presumably as a consequence of vaginal delivery.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.