Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the MyoRobot Technology.
Charlotte Pollmann,Michael Haug,Barbara Reischl,Gerhard Prölß,Thorsten Pöschel,Stefan J. Rupitsch,Christoph S. Clemen,Rolf Schröder,Oliver Friedrich +8 more
TL;DR: It is demonstrated that R349P desmin presence predominantly increased axial stiffness in both muscle types with a pre-aged phenotype over wild type fibers, suggesting that compromised muscle biomechanics is not exclusively attributed to fibrosis but also originates from an impaired intermediate filament network.
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Modelling intra-muscular contraction dynamics using in silico to in vivo domain translation
TL;DR: In this article , a 3D cycle generative adversarial network (cycleGAN) was used to model the authentic intra-muscular skeletal muscle contraction pattern using domain-to-domain translation between in-silico (simulated) and in-vivo image sequences of muscle contraction dynamics.
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Correction: Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity
Gregory Lacraz,André-Jean Rouleau,Vanessa Couture,Thomas Söllradl,Geneviève Drouin,Noémie Veillette,Michel Grandbois,Guillaume Grenier +7 more
TL;DR: This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding.
Ultrastructure Alterations in Pathological Fibrotic Skeletal Muscle of Mice and Humans
TL;DR: It was found that all of the four main stiffness collagen isoforms have a 2.46 ± 0.19 fold increase in CP, which may suggest that increased stiffness in fibrosis could be due to irregular ECM remodeling.
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Computational modeling of damage in the hierarchical microstructure of skeletal muscles.
Jens Lamsfuss,Swantje Bargmann +1 more
TL;DR: In this paper , the authors analyzed the damage behavior on hierarchy levels 3 (muscle fiber) and 4 (fascicle) on which the most common serious muscle injuries occur and showed that high strains in pre-damaged fiber regions are not transferred by the endomysium and, thus, adjacent undamaged fibers are well protected.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.