Elucidation of extracellular matrix mechanics from muscle fibers and fiber bundles.
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TLDR
A new method to quantify viscoelastic ECM modulus is presented by combining tests of single muscle fibers and fiber bundles, which demonstrate that ECM is a highly nonlinearly elastic material, while muscle fibers are linearly elastic.About:
This article is published in Journal of Biomechanics.The article was published on 2011-02-24 and is currently open access. It has received 156 citations till now. The article focuses on the topics: Skeletal muscle.read more
Citations
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Journal ArticleDOI
Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles.
Piero G. Pavan,Elena Monti,Michela Bondì,Chenglei Fan,Carla Stecco,Marco Narici,Carlo Reggiani,Lorenzo Marcucci +7 more
TL;DR: It is concluded that, in human skeletal muscles, the age-related reduced compliance is due to an increased stiffness of ECM, mainly caused by collagen accumulation.
Journal ArticleDOI
Extracellular matrix: an important regulator of cell functions and skeletal muscle development.
Weiya Zhang,Yuan Liu,Hong Zhang +2 more
TL;DR: Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which is of great significance to tissue development as mentioned in this paper and plays an important role in the physiological functions of muscle cells, such as the transmission of mechanical force, regeneration of muscle fiber, and the formation of neuromuscular junction.
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Passive mechanical properties of rat abdominal wall muscles suggest an important role of the extracellular connective tissue matrix.
TL;DR: Interestingly, across all four muscles, slack sarcomere lengths were quite long in individual muscle fibers, and demonstrated a significantly longer slack length in comparison to fiber bundles, and the extracellular connective tissue matrix provided a stiffening effect and enhanced the resistance to lengthening at long muscle lengths.
Journal ArticleDOI
Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles
TL;DR: In contrast to other pelvic tissues, pelvic floor muscle stiffness increased in pregnancy, returning to prepregnancy state postpartum, which may shield myofibers from excessive mechanical strain during parturition.
Journal ArticleDOI
Fibrillar Collagen Organization Associated with Broiler Wooden Breast Fibrotic Myopathy.
TL;DR: Comparing the structure and organization of fibrillar collagen by using transmission electron microscopy in two fast-growing broiler lines with incidence of Wooden breast to a slower growing broiler Line C with no phenotypically detectable WB is suggestive of different fibrotic myopathies beyond just what is classified as WB in fast- growing broilers.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Penney M. Gilbert,Karen Havenstrite,Klas E. G. Magnusson,Klas E. G. Magnusson,Alessandra Sacco,Nora Leonardi,Nora Leonardi,Peggy E. Kraft,N. K. Nguyen,Sebastian Thrun,Matthias P. Lutolf,Helen M. Blau +11 more
TL;DR: Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, it is shown that substrate elasticity is a potent regulator of MuSC fate in culture.
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Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis
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Cell surface receptors for extracellular matrix molecules
Clayton A. Buck,Alan F. Horwitz +1 more
TL;DR: Avian integrin shows little specificity and appears to behave as a multifunctional, promiscuous receptor for extracellular matrix molecules, and post-translational modifications provide yet another mechanism for regulating integrin-ligand binding.
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Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments.
Henk Granzier,Thomas C. Irving +1 more
TL;DR: The passive tension-sarcomere length relation of rat cardiac muscle was investigated by studying passive (or not activated) single myocytes and trabeculae and the contribution of collagen, titin, microtubules, and intermediate filaments to tension and stiffness was investigated.