Embelin. A natural potential cosmetic agent
01 Jan 2011-
TL;DR: The characteristics studies reveal the properties of embelin from E.ribes berries are on par with the standard embelin received from Sigma (USA), potentially application in cosmetic industries.
Abstract: Summary Embelia ribes one of the Indian traditional medicinal plant, has been used as a cosmetic agent to cure skin disorders for centuries. E.ribes is used especially for dyeing hairs, good pimple remover, treating acne, treating carbuncle infections, treating vitiligo and leucoderma. E.ribes berries contain a quinone derivative embelin (2,5-dihydroxy -3-undecyl,1,4- benzoquinone), has a wide spectrum of biological activities, such as antioxidant, antitumor, anti-inflammatory and analgesic, antihelmintic, antifertility and antimicrobial. Quinone derivatives and the analogs; Ubiquinone (Coenzyme Q10), Idebenone, Arbutin and Hydroquinone are well-known for cosmetic applications. In the present study, embelin from E.ribes berries of Indian origin was extracted and characterized by UV and FTIR analyses. Hemolytic, tyrosinase and DOPA auto-oxidation assays were also carried out. About 1.9± 0.1 gram of pure embelin was obtained from 100 gram of powdered berries (E.ribes). The characteristics studies reveal the properties are on par with the standard embelin received from Sigma (USA). The halfmaximal effective concentration (ED50) of embelin to cause hemolysis was found as 109± 0.1 ug/ml. The tyrosinase inhibitory activity of embelin was nil and the DOPA auto-oxidation activity was observed up to 350 µg /ml concentration. Thus the embelin finds, potentially application in cosmetic industries.
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01 Jan 2014
TL;DR: The present review exemplifies the collective knowledge on therapeutic, pharmacological and medicinal applications of embelin and can be considered as second solid gold of India next to curcumin with respect to wide spectrum of biological activities.
Abstract: Embelia ribes Burm f. (Myrsinaceae), an important traditional medicinal plant of Indian origin reported to be available in the Western Ghats of Tamil Nadu, Karnataka, Northern- eastern and Kerala state. E. ribes fruits contain a quinone derivative, embelin, an alkaloid christembine, a volatile oil and vilangin. Among them, embelin is the major bioactive constituents and marker compound in E. ribes berries. Embelin (2, 5-dihydroxy-3-undecyl-1, 4-benzoquinone) has a wide spectrum of biological activities, including antioxidant, antitumor, anti-inflammatory, analgesic, anthelmintic, antifertility and antimicrobial. The present review exemplifies the collective knowledge on therapeutic, pharmacological and medicinal applications of embelin. The development of this knowledge with perspectives of conservation, efficacy, safety and quality this will help not only to preserve this traditional heritage but also to rationalize the use of active compound in health care without any side effects. Our research on UVB protective effect of embelin using cell lines suggests, the antioxidant property prevents the irradiation damages. Considering the recent scientific bandwagon that multi-targeted is better than mono-targeted therapy for most curable diseases, embelin can be considered as an ideal life-saver drug. It can be considered as second solid gold of India next to curcumin with respect to wide spectrum of biological activities.
23 citations
Cites methods from "Embelin. A natural potential cosmet..."
...Recently in our laboratory we observed enhancing pigmentation of human skin/hair by embelin via promoting tyrosinase activity [85]; (c ) Renuka et al [86] prepared polymer material in the presence of embelin and studied the biodegradable nature of the resultant polymer; (d) Embelin has also been used as an analytical agent according to Bheemasankara rao et al [87-88] for the estimation of uranium and thorium, copper and cadmium; (e) Kalaselvi and Renuka [89] reported embelin as a cathode electrode agent in a zinc based secondary battery using ZnCl2-NH4Cl electrolyte....
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01 Jan 2015
TL;DR: The lBiodiversity of lianas under the series lSustainable development and Biodiversityr is unique as it covers a wide array of topics in this subject covering all continents and will constitute a valuable reference material for students, researchers and forest managers who are concerned with biodiversity, forest ecology and sustainable development of forest resources as mentioned in this paper.
Abstract: This book lBiodiversity of lianasr under the series lSustainable development and Biodiversityr is unique as it covers a wide array of topics in this subject covering all continents and will constitute a valuable reference material for students, researchers and forest managers who are concerned with biodiversity, forest ecology and sustainable development of forest resources. It contains peer-reviewed chapters from leading academicians and researchers around the world in the field of Plant Ecology, Taxonomy and related areas of Biodiversity Science but, centered on Lianology and includes original research articles, case studies and reviews (regional and global) in biodiversity, ecology and phytogeography and conservation of lianas from temperate, sub-tropical and tropical forests. The interest in lianas has increased over the last two decades. The ultimate goal of this book is to provide an insight into the patterns of liana diversity, distribution, the role of lianas in structuring forest community, and functional ecology (carbon uptake, ecosystem services, dynamics and invasion), biotechnological tool for conservation of lianas and finally summarizes the significance and the need for conservation of lianas in the changing global environmental scenario.
16 citations
TL;DR: Assessment of anti-melanoma activity of the two benzoquinones found rapanone showed selective and higher than doxorubicine cytotoxic potential against primary melanoma cell line, WM793 and embelin revealed higher albumin anti-denaturation potential than rapan one but lower than diclofenac sodium.
15 citations
TL;DR: A highly comprehensive review has been under taken to highlight the areas of research where in this particular species is extensively studied and the current status of this important threatened medicinal plant.
Abstract: Embelia ribes Burm.f. is a threatened medicinal plant, studied extensively for its rich medicinal properties. It has been used in ayurvedic formulations from the ancient times and in the recent past a surge of research on this particular medicinal plant species has been undertaken. This particular species is found to attribute to a number of medicinal properties such as antidiabetic, anticancer, antimicrobial, antitumor, antifertility activity and many more. Hence this highly comprehensive review has been under taken to highlight the areas of research where in this particular species is extensively studied and the current status of this important threatened medicinal plant.
10 citations
01 Jan 2015
TL;DR: The status of biotechnology of medicinal lianas of India is reviewed and the novel combinations to achieve the desired results are discussed to help in deciding the priorities for further technology development for production of useful metabolites and multiplication of lianAs in mass scale.
Abstract: Medicinal lianas of India are source of several important secondary metabolites which have great potential for future therapeutics. Because of their overexploitation using destructive harvesting methods and/or with some reproductive barriers, most of them have become threatened species. Recent biotechnological developments depicting their biological activity, standardizing the micropropagation methods, and development of callus and cell cultures for the production of useful metabolites have opened up novel ways for their conservation by reducing pressure on their natural populations. Though considerable success has been achieved in developing the micropropagation protocols as well as bioreactor level production of secondary metabolites for some lianas, yet for many lianas development of these technologies remained a challenge. This article reviews the status of biotechnology of medicinal lianas of India and discusses the novel combinations to achieve the desired results. The review is expected to help in deciding the priorities for further technology development for production of useful metabolites and multiplication of lianas in mass scale.
5 citations
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Journal Article•
TL;DR: This review attempts to portray the discovery and development of medicine from galenical to genomical, with a focus on the potential and role of ayurveda.
Abstract: This review attempts to portray the discovery and development of medicine from galenical to genomical, with a focus on the potential and role of ayurveda. Natural products, including plants, animals and minerals have beenthe basis of treatment of human diseases. Indigenous people derived therapeutic materials from thousands of plants; however discovering medicines or poisons remains a vital question. Ayurveda is a traditional Indian medicinal system being practised for thousands of years. Considerable research on pharmacognosy, chemistry, pharmacology and clinical therapeutics has been carried out on ayurvedic medicinal plants. Many of the major pharmaceutical corporations have renewed their strategies in favour of natural products drug discovery and it is important to follow systems biology applications to facilitate the process. Numerous drugs have entered the international pharmacopoeia through the study of ethnopharmacology and traditional medicine. For ayurveda and other traditional medicines newer guidelines of standardization, manufacture and quality control are required. Employing a unique holistic approach, ayurvedic medicines are usually customized to an individual constitution. Traditional knowledge-driven drug development can follow a reverse pharmacology path and reduce time and cost of development. New approaches to improve and accelerate the joint drug discovery and development process are expected to take place mainly from innovation in drug target elucidation and lead structure discovery. Powerful new technologies such as automated separation techniques, high-throughput screening and combinatorial chemistry are revolutionizing drug discovery. Traditional knowledge will serve as a powerful search engine and most importantly, will greatly facilitate intentional, focused and safe natural products research to rediscover the drug discovery process.
457 citations
TL;DR: The medicinal plants used by the people of Assam for curing different skin ailments and for cosmetics ranges from the enhancement of skin colour, hair care, removal of ugly spots, colouring of nails, palms, and teeth, but many of the plant preparations used for enhancing beauty were also applied for therapeutic use.
236 citations
TL;DR: Ethanol extract of the leaves of Embelia ribes Burm and its isolated quinone compound embelin were screened for wound healing activity by excision, incision and dead space wound models on Swiss Albino Rats and histological examination of the granulation tissue of embelin treated group showed increased cross-linking of collagen fibers and absence of monocytes.
176 citations
TL;DR: Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholanthrene-induced fibrosarcoma in albino rats besides enhancing their survival time and has an appreciable action on pain and inflammation.
Abstract: Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholan-threne-induced fibrosarcoma in albino rats besides enhancing their survival tim
162 citations
01 Jan 2004
TL;DR: The side e ffects and adverse reactions/ interactions of few most commonly used herbs considered to be safe since centuries arelighted with an advise to the physicians and pharmacists to consider the health hazards associated with the use of such drugs while taking the history of the patients.
Abstract: SUMMARY The last decade has witnessed a great revival of interest in the use of herbal medicines both in the developed as well as developing countries. Almost 50% of the medicines we use today are derived straight from plants and 25% of t he p rescription drugs have their genesis of tropical plants*. According to WHO, 80% of the world population rely c hiefly on p lant based traditional medicines s pecially for their primary health care nee ds. The common belief based on tradition, that medicinal plants being "natural" or near to nature are always safe, is not held to be true lately. The advancement of technology has enabled the scientists to detect minute amounts of carcinogenic and toxic chemicals in these herbs and recognize or evaluate potentially hazardous effects of some of t he he rbs used in traditional medicines s ince centuries. This article a ims to h ighlight the side e ffects and adverse reactions/ interactions of few most commonly used herbs considered to be safe since centuries with an advise to the physicians and pharmacists to consider the health hazards associated with the use of such drugs while taking the history of the patients.
129 citations