Emerging SARS-CoV-2 variants of concern and potential intervention approaches.
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TLDR
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome as discussed by the authors.Abstract:
The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome. The spike protein mutations and other non-structural protein mutations in the VOCs may lead to escape approved vaccinations in certain extend. We will discuss these VOC mutations and discuss the need for combination therapeutic strategies targeting viral cycle and immune host responses.read more
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Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis
Stella Talic,Shivangi Shah,Holly Wild,Danijela Gasevic,Danijela Gasevic,Ashika D. Maharaj,Zanfina Ademi,Xue Li,Xue Li,Wei Xu,Ines Mesa-Eguiagaray,Jasmin Rostron,Evropi Theodoratou,Xiaomeng Zhang,Ashmika Motee,Danny Liew,Dragan Ilic +16 more
TL;DR: A systematic review and meta-analysis suggests that several personal protective and social measures, including handwashing, mask wearing, and physical distancing are associated with reductions in the incidence covid-19 as mentioned in this paper.
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Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
TL;DR: In this article , the authors assessed the antiviral activity of remdesivir and its parent nucleoside GS-441524, molnupiravir and their parent EIDD-1931 and the viral protease inhibitor nirmatrelvir against the ancestral SARS-CoV2 strain and the five variants of concern including Omicron.
Journal ArticleDOI
SARS-COV-2 Variants: Differences and Potential of Immune Evasion
Sandro M. Hirabara,Tamires Duarte Afonso Serdan,Renata Gorjão,Laureane Nunes Masi,Tania Cristina Pithon-Curi,Dimas Tadeu Covas,Rui Curi,Edison Luiz Durigon +7 more
TL;DR: This review addressed the following critical points concerning VOCs: characteristics of the SARS-CoV-2 V OCs with mutations in the S gene, possible evasion of variants from neutralizing antibodies generated through vaccination, previous infection, or immune therapies, potential risk of new pandemic waves induced by the variants worldwide, and perspectives for further studies and actions.
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How the coronavirus infects cells - and why Delta is so dangerous.
TL;DR: In this article, the authors unpacked the life cycle of SARS-CoV-2 and how the virus uses tricks to evade detection and showed that the virus can evade detection.
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SARS-CoV-2 Mutations and Their Impact on Diagnostics, Therapeutics and Vaccines
Suresh Thakur,Shalitha Sasi,Sindhu Gopinathan Pillai,Ayantika Nag,Dhananjay Shukla,Ritu Singhal,Sameer Phalke,Geetha Velu +7 more
TL;DR: The mutational landscape on the SARS-CoV-2 structural and non-structural proteins and their impact on diagnostics, therapeutics and vaccines are reviewed and the effectiveness of approved vaccines, antibody therapy and convalescent plasma on the currently prevalent VOCs are looked at.
References
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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