Emerging strategies to boost thymic function
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TLDR
Three strategies have been developed to enhance and repair thymus function in the elderly and in individuals undergoing hematopoietic stem cell transplantation that include the use of sex steroid ablation, the administration of growth and differentiation factors, and the transfer of T cell progenitors to alleviate the effects ofThymus dysfunction and consequent T cell deficiency.About:
This article is published in Current Opinion in Pharmacology.The article was published on 2010-08-01 and is currently open access. It has received 73 citations till now. The article focuses on the topics: T cell & Involution (medicine).read more
Citations
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Interleukin-22: Immunobiology and Pathology
TL;DR: The current understanding of IL-22 is assessed, including its physiologic and pathologic effects on epithelial cell function, which are linked to several conditions involving inflammatory tissue pathology.
Journal ArticleDOI
Causes, consequences, and reversal of immune system aging
TL;DR: The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues, and elderly individuals do not respond to immune challenge as robustly as the young.
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Thymic T-cell development in allogeneic stem cell transplantation.
TL;DR: The identification of the cellular and molecular mechanisms that control regular thymopoiesis but are altered in HCT patients is expected to provide the basis for new therapies that improve the regeneration of the adaptive immune system, especially with functionally competent, naive T cells.
Journal ArticleDOI
Gain and Loss of T Cell Subsets in Old Age—Age-Related Reshaping of the T Cell Repertoire
Christoph R. Arnold,Juliane Wolf,S. E. Brunner,Dietmar Herndler-Brandstetter,Beatrix Grubeck-Loebenstein +4 more
TL;DR: This review focuses on the major age-related changes that occur in the naïve and the antigen-experienced T cell population and discusses the mechanisms responsible for the generation and maintenance of these subsets and how age- related changes can be delayed or prevented by clinical interventions.
Gain and loss of T cell subsets in old age – Age-related reshaping of the T cell repertoire
Christoph R. Arnold,Juliane Wolf,S. E. Brunner,Dietmar Herndler-Brandstetter,Beatrix Grubeck-Loebenstein +4 more
TL;DR: In this paper, the authors focus on the major age-related changes that occur in the naive and the antigen-experienced T cellpopulation, and discuss the mechanisms responsible for the generation and maintenance of these subsets and how agerelated changes can be delayed orprevented by clinical interventions.
References
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Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
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Changes in thymic function with age and during the treatment of HIV infection
Daniel C. Douek,Richard D. McFarland,Phillip H. Keiser,Earl A. Gage,Janice M. Massey,Barton F. Haynes,Michael A. Polis,Ashley T. Haase,Mark B. Feinberg,John L. Sullivan,Beth D. Jamieson,Jerome A. Zack,Louis J. Picker,Richard A. Koup +13 more
TL;DR: It is found that, although thymic function declines with age, substantial output is maintained into late adulthood and this results indicate that the adult thymus can contribute to immune reconstitution following HAART.
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p53 status and the efficacy of cancer therapy in vivo
Scott W. Lowe,Stephan Bodis,Andrea I. McClatchey,Lee Remington,H E Ruley,David E. Fisher,David E. Housman,Tyler Jacks +7 more
TL;DR: It is established that defects in apoptosis, here caused by the inactivation of p53, can produce treatment-resistant tumors and suggested that p53 status may be an important determinant of tumor response to therapy.
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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
J J Peschon,Philip J. Morrissey,Kenneth H. Grabstein,F J Ramsdell,E Maraskovsky,Brian C. Gliniak,L S Park,Steven F. Ziegler,D E Williams,C B Ware,J. Meyer,B L Davison +11 more
TL;DR: In this paper, the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL7R was examined and it was shown that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL7.
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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.
TL;DR: The IL-7-deficient mice are the first example of single cytokine- deficient mice that exhibit severe lymphoid abnormalities and data show that proper T and B cell development is dependent on IL- 7.