Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
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Cites background from "Emodin blocks the SARS coronavirus ..."
...The mAb could efficiently neutralize SARS‐CoV and inhibit syncytia formation between cells expressing the S protein and those expressing the SARS‐CoV receptor ACE2....
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...These findings suggested that emodin and promazine might be able to in- hibit SARS‐CoV infectivity through blocking the interaction of S protein and ACE2....
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...Emodin is an anthraquinone compound derived from genus Rheum and Polygonum and it is also a virucidal agent.92 Emodin could sig- nificantly block the interaction between the S protein of SARS‐CoV and ACE2....
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...Therefore, emodin might abolish SARS‐CoV infection by competing for the binding site of S protein with ACE2.(93)...
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...Therefore, emodin might abolish SARS‐CoV infection by competing for the binding site of S protein with ACE2....
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