EMT and inflammation: inseparable actors of cancer progression
Citations
1,563 citations
362 citations
Cites background from "EMT and inflammation: inseparable a..."
...Given that cytokine secretion represents the major functional response of macrophages, it was speculated that a signaling mechanism between TAMs and CRC cells exists that accounts at least in part for the previously described pro-tumorigenic activities [27]....
[...]
355 citations
169 citations
Cites background from "EMT and inflammation: inseparable a..."
...This set of immune cells and the molecules they secrete then activate the PI3K and NF-κB signaling pathways for promoting the EMT and vasculogenic mimicry (81, 82)....
[...]
150 citations
Cites background from "EMT and inflammation: inseparable a..."
...Epithelial–mesenchymal transition (EMT), as a major actor modulating tumor metastasis [2, 3], may be involved in the interaction between the tumor cells and tumor microenviron-...
[...]
References
3,050 citations
"EMT and inflammation: inseparable a..." refers background in this paper
...CCL2 expression in cancer correlates with TAM density (Deshmane et al., 2009)....
[...]
2,140 citations
"EMT and inflammation: inseparable a..." refers background in this paper
...Indoleamine 2,3 dioxygenase (IDO) is mainly a tumor cell-derived, inflammation-induced, immunosuppressive factor (Muller et al., 2008; Uyttenhove et al., 2003) that promotes tumor progression....
[...]
2,071 citations
"EMT and inflammation: inseparable a..." refers background in this paper
...Similarly, many publications have illustrated the prometastatic effects of EMT program activation in cancer cells (Bates and Mercurio, 2005; Fassina et al., 2012; Spaderna et al., 2006; Yu et al., 2013)....
[...]
1,622 citations
"EMT and inflammation: inseparable a..." refers background in this paper
...Although two recent studies (Fischer et al., 2015; Zheng et al., 2015) have revived the debate about the universal requirement of EMT in the metastasis process, the current dogma is that EMT processes might be involved in the initial steps of the metastatic cascade, including tumor invasion, intravasation, and micrometastases formation....
[...]
...Although two recent studies (Fischer et al., 2015; Zheng et al., 2015) have revived the debate about the universal requirement of EMT in the metastasis process, the current dogma is that EMT processes might be involved in the initial steps of the metastatic cascade, including tumor invasion,…...
[...]
1,488 citations
"EMT and inflammation: inseparable a..." refers background in this paper
...Although two recent studies (Fischer et al., 2015; Zheng et al., 2015) have revived the debate about the universal requirement of EMT in the metastasis process, the current dogma is that EMT processes might be involved in the initial steps of the metastatic cascade, including tumor invasion,…...
[...]