Journal ArticleDOI
Enabling stem cell based therapies: end-to-end solution for human pluripotent stem cells manufacturing
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This platform avoids 2D cell culture steps, reduces footprint, labor and cost, while enhancing process control and cell product quality, and shows that hPSCs expanded in a bioreactor are shown to have the capability to be directly differentiated in suspension.About:
This article is published in Cytotherapy.The article was published on 2019-05-01. It has received 1 citations till now.read more
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Journal ArticleDOI
End-to-End Platform for Human Pluripotent Stem Cell Manufacturing.
Puspa R. Pandey,Amarel Tomney,Marites T. Woon,Nicholas Uth,Farjad Shafighi,Igor Ngabo,Haritha Vallabhaneni,Yonatan Levinson,Eytan Abraham,Inbar Friedrich Ben-Nun +9 more
TL;DR: A closed, automated and scalable stirred tank bioreactor platform, capable of sustaining high fold expansion of human pluripotent stem cells, that could facilitate the in-process monitoring and integration of online monitoring systems, leading to significantly reduced labor requirements and contamination risk.