Journal ArticleDOI
Enaminones: versatile intermediates for natural product synthesis*
Joseph P. Michael,C. B. De Koning,David Gravestock,Gladys D. Hosken,Arthur S. Howard,C. M. Jungmann,Rui W. M. Krause,Andrew S. Parsons,Stephen C. Pelly,Trevor V. Stanbury +9 more
Reads0
Chats0
TLDR
In this article, an overview of the chemistry of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2, S O 2Ar, etc.).Abstract:
Efforts in our laboratories to devise a general approach to the synthesis of alkaloids focus on the versatile reactivity of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2 ,S O 2Ar, etc.). This lecture presents an overview of our research with these useful building blocks. Themes to be elaborated include chemo- selectivity and diastereoselectivity in reactions of enaminones, and the challenge of controlling absolute stereochemistry.read more
Citations
More filters
Journal ArticleDOI
One-Pot Solvent-Free Three-Component Synthesis of Conjugated Enaminones Containing Three Alkyl Carboxylate Groups
TL;DR: In this article, an effective one-pot, multicomponent, and solvent-free reaction for conjugated enaminones containing three alkyl carboxylate groups was described.
Journal ArticleDOI
1-(p-Tolylsulfonyl)propan-2-one
TL;DR: The asymmetric unit of the title compound, C10H12O3S, contains two independent mol-ecules having different conformations as mentioned in this paper, in one conformation the aromatic ring and the acetyl substituent are gauche to each other, while in the other they are anti.
Journal ArticleDOI
Studying the geometric parameters, stability of isomer and IR frequencies in enaminone compounds with the DFT and HF methods: A theoretical study
TL;DR: In this article, Sustainability and inter-molecular hydrogen bond strength of each isomer of enaminone is investigated and the results of calculations in geometry parameters indicated that in their parameters, B3P86 method and 6-311++G** basis set have considerable preference than other methods and basis sets.
Book ChapterDOI
Five-Membered S-Heterocycle Synthesis
TL;DR: Lawesson's reagent is a general sulfuration reagent which can convert carbonyl group of aldehydes, ketones, amides, or esters to thiocarbonyl species as mentioned in this paper.
Journal ArticleDOI
SYNTHESIS OF A NEW C-15 PHOSPHORUS YLIDE USED FOR THE PREPARATION OF SOME β-END-GROUP RETINOID DERIVATIVES
TL;DR: In this article, a synthesis of a new C-15 phosphorus ylide from a C-14 enaminone was reported, which undergoes selective 1,2-or 1,4-additions with saturated and unsaturated aldehydes, may find some synthetic use for the preparation of β-end-group retinoid derivatives.
References
More filters
BookDOI
Alkaloids : chemical and biological perspectives
TL;DR: In this paper, the total synthesis of amaryllidaceae alkaloids has been studied using radical cyclization reactions in total syntheses of naturally occurring indole alkaloid.
Book
Strategies and Tactics in Organic Synthesis
TL;DR: This paper presents the first total Synthesis of several Natural Products Based On Alkyne-Co2(Co2)6 Complexes, and discusses the design and synthesis of Cooperative "Pinwheel" Fluorescent Sensors, and the application of Silicon-Ass Intramolecular Cross-Coupling.