Journal ArticleDOI
Enaminones: versatile intermediates for natural product synthesis*
Joseph P. Michael,C. B. De Koning,David Gravestock,Gladys D. Hosken,Arthur S. Howard,C. M. Jungmann,Rui W. M. Krause,Andrew S. Parsons,Stephen C. Pelly,Trevor V. Stanbury +9 more
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TLDR
In this article, an overview of the chemistry of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2, S O 2Ar, etc.).Abstract:
Efforts in our laboratories to devise a general approach to the synthesis of alkaloids focus on the versatile reactivity of enaminones and related compounds containing the structural unit N-CaC-Z (Za COR, CO2R, CN, NO2 ,S O 2Ar, etc.). This lecture presents an overview of our research with these useful building blocks. Themes to be elaborated include chemo- selectivity and diastereoselectivity in reactions of enaminones, and the challenge of controlling absolute stereochemistry.read more
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Journal ArticleDOI
(2E)-1-Phenyl-2-[1-(2-phenyl-prop-2-en-1-yl)pyrrolidin-2-yl-idene]ethanone.
TL;DR: The title compound, C21H21NO, is a vinylogous amide (enaminone) produced by reaction of 1-(2-phenylprop-2-en-1-yl)pyrrolidine- 2-thione with phenacyl bromide.
Journal ArticleDOI
2-[(2Z)-Azepan-2-yl-idene]-1-(4-nitro-phen-yl)ethanone.
TL;DR: The title compound, C14H16N2O3, is an NH-vinylogous amide (enaminone) produced by the reaction of 4-nitrophenacyl bromide with azepane-2-thione.
Book ChapterDOI
O- and N-Heterocycles Synthesis
TL;DR: The phosphorus pentasulfide remained as the key reagent from the 2nd half of the nineteenth century until the beginning of systematic study of the utilization of Lawesson's reagent in 1978.
Electronic structures, intramolecular hydrogen bond interaction, and aromaticity of substituted 4-amino-3-penten-2-one in ground and electronic excited state
TL;DR: In this paper, the time-dependent density functional theory (TD-DFT) was used to evaluate the hydrogen bond strength, molecular struc- ture, and several well-established indices of aromaticity for 4-amino-3-penten-2-one and its 20 derivatives.
References
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BookDOI
Alkaloids : chemical and biological perspectives
TL;DR: In this paper, the total synthesis of amaryllidaceae alkaloids has been studied using radical cyclization reactions in total syntheses of naturally occurring indole alkaloid.
Book
Strategies and Tactics in Organic Synthesis
TL;DR: This paper presents the first total Synthesis of several Natural Products Based On Alkyne-Co2(Co2)6 Complexes, and discusses the design and synthesis of Cooperative "Pinwheel" Fluorescent Sensors, and the application of Silicon-Ass Intramolecular Cross-Coupling.