Endemic Sardinian plants: the case of Genista cadasonensis Valsecchi
TL;DR: The flavonoid fraction of the aerial parts of Genista cadasonensis Valsecchi (Leguminosae), an endemic plant from Sardinia, was examined and shown the presence of a rare flavonoids, the 6-hydroxy-genistein.
About: This article is published in Natural Product Research.The article was published on 2010-05-19. It has received 11 citations till now. The article focuses on the topics: Genista.
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TL;DR: Evaluation of percentage of inhibition of DPPH radical by the purified isoflavone 4 from the root extract showed that it affords a moderate contribution to the total radical scavenging activity of the extract.
Abstract: Genista species are sources of antioxidant phenolic compounds such as O- and C-glycosylflavonoids and isoflavonoids. A combination of a DPPH scavenging assay with HPTLC-MS, a fast and efficient method for identification of bioactive compounds, has been applied for evaluation of the radical scavenging activity of metabolites from Genista saharae Coss. a Dur. Different organs collected at various periods have been compared. Identification of antioxidant compounds was obtained by elution of the major DPPH-inhibition zones. The resulting HPTLC-MS analysis under moderately polar conditions, coupled to the DPPH results led to the putative identification of two antioxidant isoflavone aglycones: 3',4',5,7-tetrahydroxyisoflavone (1) and ficuisoflavone (3), whereas polar migration conditions led to the identification of the glycosides 5-methoxy-4',7-trihydroxy-8-glucopyranosylisoflavone (4) and 4',5-dihydroxy-7-methoxyisoflavone-4'-O-β-D-gluco-pyranoside (5). Evaluation of percentage of inhibition of DPPH radical by the purified isoflavone 4 from the root extract showed that it affords a moderate contribution to the total radical scavenging activity of the extract.
24 citations
TL;DR: The HD oil revealed an important inhibitory effect on germ tube formation in C. albicans at sub-inhibitory concentrations, and at the concentration of 1/16 MIC the inhibition of filamentation was more than 70% in comparison to untreated control cells.
17 citations
TL;DR: In this review, studies on the molecular pattern of endemic plants of restricted areals (Sardinia Island and Central Italy with Monti Sibillini National Park and Majella National Park) are reported, with particular attention toward plants containing active compounds and plants with an ethnopharmacologic history and tradition.
Abstract: Chemistry of natural organic products regards studies of molecular structural characters devoted to the identification of new molecular architectures and searching new compounds present in natural matrices characterized by biological useful activity. More recently, particular attention has been directed to phytochemical studies of plants, the so-called endemic species, growing in particular areas, characterized by narrow limits. The hypothesis is that a wide variety of climates, environmental, geological, geographical, and biological conditions has led to the diversification of species. Endemism is the condition of being restricted to a particular area with a prescribed extent and describes species that are native to a particular geographic territory, and usually occurs in areas that are in some way isolated. The term “endemism” derives from the medical language and it was used for the first time, referred to plants, in 1820 by De Candolle. It is possible to distinguish several categories of endemisms. In 1926 Herzog sets the differences between neoendemics and paleoendemics species. Favarger & Contandriopoulos in 1961 and Favarger in 1964 proposed a new classification based on the mode of genesis of the species: schizoendemism, apoendemism, patroendemism, and paleoendemism. Paleoendemism and patroendemism represent the conservative component of the flora of a territory while schizoendemism and apoendemism represent the innovating component of it. Like other Mediterranean-type ecosystems, the Mediterranean Basin has high levels of plant diversity and endemism. The floral diversity of the Mediterranean Basin is dramatic. Its 25,000 vascular plants species (13,000 endemic species) are more than four times the number found in all the rest of Europe. The Mediterranean region constitutes both a refuge area and one that encourages floral exchange and active plant speciation. Many of the endemic species are concentrated on islands, peninsulas, cliffs, and peaks. In this review, studies on the molecular pattern of endemic plants of restricted areals (Sardinia Island and Central Italy with Monti Sibillini National Park and Majella National Park) are reported, with particular attention toward plants containing active compounds and plants with an ethnopharmacologic history and tradition. These two areas were selected as representative sites of insular and peninsular areas of Italy.
15 citations
29 Jul 2020
TL;DR: An up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations is provided.
Abstract: The last decades have recorded an increase of plant-based drug discovery processes. Indeed, natural products possess a superior chemical diversity as compared to synthetic ones, leading to a renewal in searching for new therapeutic agents from the plant kingdom. In particular, since the structural variety of natural compounds reflects the biodiversity of their source organisms, regions of the world with high biodiversity and endemism deserve particular interest. In this context, Sardinia Island (Italy), with 290 endemic taxa (12% of the total flora), is expected to provide unique and structurally diverse phytochemicals for drug development. Several research groups built up a large program dedicated to the analysis of Sardinian endemic species, highlighting their peculiar features, both in respect of phytochemical and biological profiles. On this basis, the aim of this review is to provide an up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations. We documented 152 articles published from 1965 to June 2020 in which a broad range of biological activities and the identification of previously undescribed compounds have been reported, supporting their great value as sources of therapeutic agents.
12 citations
TL;DR: The experimental findings indicated that genistin, isosalipurpol, and koaburaside have moderate to low antibacterial activity against E. aureus, S. epidermidis and P. aeruginosa bacteria with MICs ranging from 31.2 to 125 μg/mL.
9 citations
Additional excerpts
...…7-O-β-d-glucopyranosyl-4′dihydroxyflavone (12) (Nascimento and Oliveira 2004), cynaroside (13) (Furkan et al. 2012), genistein (14)and daidzin (15) (Shimoda et al. 2006), genistin (16) (Yuldashev et al. 1990), sissotrin (17) (Fu et al. 2012), 8-C-β-d-glucopyranosyl-genistein (18) and…...
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...2012), genistein (14)and daidzin (15) (Shimoda et al. 2006), genistin (16) (Yuldashev et al....
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References
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TL;DR: In this article, 10 phenolic compounds were isolated from a butanol fraction of sage extracts and their structures were determined by spectral methods (NMR, MS, IR). Among them, a novel compound, 4-hydroxyacetophenone-4-O-β-d-apiofuranosyl-(1→6)-O- β-dglucopyranoside, was identified.
Abstract: Ten phenolic compounds were isolated from a butanol fraction of sage extracts. Their structures were determined by spectral methods (NMR, MS, IR). Among them, a novel compound, 4-hydroxyacetophenone-4-O-β-d-apiofuranosyl-(1→6)-O-β-d-glucopyranoside, was identified. Two test systems, DPPH free radical scavenging activity and radical cation ABTS•+ scavenging activity, were used to evaluate their antioxidant activity. The most active compounds were found to be rosmarinic acid and luteolin-7-O-β-glucopyranoside. Keywords: Sage; Salvia officinalis; phenolic compounds; antioxidant activity
643 citations
"Endemic Sardinian plants: the case ..." refers methods in this paper
...DPPH method Free-radical scavenging activity of the extracts was determined using a method based on the reduction of a methanolic solution of the colour-free radical DPPH (1,1-diphenyl-2picrylhydrazyl) (Wang et al., 1998), modified as reported in Poli et al....
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...DPPH method Free-radical scavenging activity of the extracts was determined using a method based on the reduction of a methanolic solution of the colour-free radical DPPH (1,1-diphenyl-2picrylhydrazyl) (Wang et al., 1998), modified as reported in Poli et al. (2003)....
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TL;DR: Three new flavonoids were isolated from the aerial parts of Genista ephedroides by means of spectroscopic methods and established as hydroxyalpinumisoflavone, ephedroidin and genisteone.
Abstract: Three new flavonoids (1-3) and 11 known compounds (genistein, isoprunetin, wighteone, laburnetin, alpinumisoflavone, genistin, genistein 8-C-glucoside, apigenin, isokaempferide, licoflavone C, and D-pinitol) were isolated from the aerial parts of Genista ephedroides. The structures of the new compounds were established as hydroxyalpinumisoflavone (1) [4', 5-dihydroxy-2"-methyl-2"-hydroxymethylpyrano(5",6":6,7)isoflavone], ephedroidin (2) [4',5, 7-trihydroxy-8-(2-hydroxy-3-methyl-3-butenyl)flavone], and genisteone (3) (7-O-glucosylwighteone) by means of spectroscopic methods.
36 citations
"Endemic Sardinian plants: the case ..." refers background in this paper
...ephedroides (Pistelli et al., 1998) Genistein, isoprunetin, wighteon, laburnetin, alpinumisoflavon, genistin, apigenin, isokaempferide, licoflavon C hydroxy-alpinum-isoflavon, efedroidin, genisteon, pinitol G....
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...In G. corsica (Pistelli et al., 2000) and G. morisii (Giachi et al., 2002) luteolin (1) was isolated, while G. ephedroides (Pistelli et al., 1998) and G. morisii....
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TL;DR: 6-Hydroxygenistein and calycosin are the probable precursors of a number of known naturally occurring isoflavones.
29 citations
TL;DR: A new isoflavone (1), dihydroisoderrondiol, was isolated from aerial parts of Genista corsica and elucidated by spectroscopic methods.
Abstract: A new isoflavone (1), dihydroisoderrondiol [(3‘ ‘S,4‘ ‘R)-5,7,3‘ ‘,4‘ ‘-tetrahydroxy-2‘ ‘,2‘ ‘-dimethyl-3‘ ‘,4‘ ‘-dihydropyrano(5‘ ‘,6‘ ‘;3‘ ‘,4‘ ‘)isoflavone], was isolated from aerial parts of Ge...
28 citations
"Endemic Sardinian plants: the case ..." refers background in this paper
...Compound 4 was also isolated in two endemic Sardinian species of this genus: G. corsica (Pistelli et al., 2000) and G. ephedroides (Giachi et al., 2002)....
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...In G. corsica (Pistelli et al., 2000) and G. morisii (Giachi et al., 2002) luteolin (1) was isolated, while G. ephedroides (Pistelli et al., 1998) and G. morisii....
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...corsica (Pistelli et al., 2000) Luteolin di-hydroxy-derrondiol, daidzein, isoprunetin, isoderrone, ficu-isoflavon, taxifolin, 5-methoxytaxifolin, pinitol G....
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TL;DR: In this paper, the antioxidant activity of supercritical CO 2 extracts of H. italicum dried flower heads derived from the commercial drug and from plants grown in different areas of north-east Italy with different culturing conditions was determined.
Abstract: The antioxidant activity of supercritical CO 2 extracts of H. italicum dried flower heads derived from the commercial drug and from plants grown in different areas of north-east Italy with different culturing conditions was determined. In particular, the characterization of the antioxidant activity was made by the DPPH and s-carotene bleaching test methods. The four kind of H. italicum extracts were also tested for their ability to scavenger superoxide radicals. All extracts showed, although with different importance, an antioxidant activity with all the methods performed. The supercritical extracts obtained from commercial dried H. italicum flower heads and from dried flower heads belonging to wild plants exhibited the highest activity. These results established H. italicum supercritical extracts as important antioxidant solvent-free matrices in alimentary (i.e., dietary, nutraceutical, flavouring) and cosmetic fields, as well as the value of coastal Mediterranean areas to serve as an exploitable source ...
28 citations
"Endemic Sardinian plants: the case ..." refers methods in this paper
...DPPH method Free-radical scavenging activity of the extracts was determined using a method based on the reduction of a methanolic solution of the colour-free radical DPPH (1,1-diphenyl-2picrylhydrazyl) (Wang et al., 1998), modified as reported in Poli et al. (2003)....
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