Endogenous Superoxide Dismutase Levels Regulate Iron-Dependent Hydroxyl Radical Formation in Escherichia coli Exposed to Hydrogen Peroxide
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119 citations
Additional excerpts
...coli cells exposed to hydrogen peroxide (39)....
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113 citations
Cites background from "Endogenous Superoxide Dismutase Lev..."
...cycling compounds, and mutants that lack cytoplasmic SODs contain almost 10 times the amount of Fe(2) found in wild-type cells (24)....
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99 citations
Cites background from "Endogenous Superoxide Dismutase Lev..."
...reactions, results in the formation of secondary ROS such as hydrogen peroxide (H2O2; Reaction 3) and the hydroxyl radical (OH; Reaction 4) [1, 4, 5, 17]....
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...The primary ROS formed as a byproduct of this respiratory process is the superoxide anion radical (O2 ), generated when molecular oxygen gains an electron from either the mitochondrial electron transport chain (Reaction 1) or as a result of UVirradiation (Reaction 2) [1, 4, 5, 17]....
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...H2O2 reacts with redox-active metal ions to generate hydroxyl radical [5, 17, 18, 20, 28]....
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...reduction of molecular oxygen (O2) to produce water (H2O) via metabolic processes catalyzed by cytochrome oxidase in biological systems [5, 17]....
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76 citations
Cites background from "Endogenous Superoxide Dismutase Lev..."
...Previous studies have shown that the endogenous SOD levels control the iron-dependent HO formation when cells are exposed to hydrogen peroxide (13, 14, 42) or such formation is due to an iron overload as in the Fur mutant of E....
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72 citations
References
21,528 citations
"Endogenous Superoxide Dismutase Lev..." refers background in this paper
...rapidly reacts with itself (dismutes) to form H2O2 (7)....
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...Although the aerobic metabolism of bacteria optimally results in the near simultaneous four-electron reduction of O2 to H2O, a variable percentage of O2 reduction occurs initially via either one-electron reduction of O2 to superoxide (O2 ) or divalent reduction to H2O2 (7)....
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1,997 citations
"Endogenous Superoxide Dismutase Lev..." refers background in this paper
...Pretreatment of the JI132 (SOD-deficient) bacteria with DFO greatly reduced the magnitude of OH generation, confirming that it arose as a consequence of Fenton chemistry, as iron bound to DFO is no longer available for this redox chemistry (10)....
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974 citations
"Endogenous Superoxide Dismutase Lev..." refers background in this paper
...Most bacteria, including Escherichia coli, contain superoxide dismutase (SOD) and catalase as means of eliminating O2 z2 and H2O2, respectively (16, 17)....
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851 citations
803 citations