Open AccessJournal Article
Endometrial stromal sarcoma with endometrioid adenocarcinoma of the uterus: a case report.
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TLDR
The first case of undifferentiated ESS (UES) coexistent with grade 1 endometrioid adenocarcinoma in a 73-year-old female who presented with irregular vaginal bleeding for 4 days after menopause 20 years is reported.Abstract:
Endometrial stromal sarcoma (ESS) is a rare malignant neoplasm of the uterus. We report the first case of undifferentiated ESS (UES) coexistent with grade 1 endometrioid adenocarcinoma in a 73-year-old female who presented with irregular vaginal bleeding for 4 days after menopause 20 years. Imaging examination including Magnetic Resonance Imaging (MRI) demonstrated multi-node reflection in uterine cavity without metastatic lesions, and the endometrium essentially normal. Grossly, a grey-red breakable polypoid tumor of 4.5 × 3.0 ×2.0 cm was recognized in the posterior uterine wall with surrounding slight rough endometrium. Microscopically, the tumor was composed of a larger component of undifferentiated stromal sarcoma that was distinct from a smaller endometrioid adenocarcinoma. The separate components of the tumor could be supported in immunohistochemical studies. There was no sign of recurrence for postoperative 6 months.read more
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Utility of diffusion-weighted and contrast-enhanced magnetic resonance imaging in diagnosing and differentiating between high- and low-grade uterine endometrial stromal sarcoma.
Yen-Ling Huang,Yen-Ling Huang,Shir-Hwa Ueng,Kueian Chen,Kueian Chen,Yu-Ting Huang,Hsin-Ying Lu,Hsin-Ying Lu,Koon-Kwan Ng,Ting-Chang Chang,Chyong-Huey Lai,Gigin Lin,Gigin Lin +12 more
TL;DR: Diffusion-weighted MR imaging is useful in diagnosing ESS against T2-hyperintense leiomyomas, and contrast enhancement aids in further differentiating between high- and low-grade ESS.
Journal ArticleDOI
Collision Tumor of Endometrial Large Cell Neuroendocrine Carcinoma and Low-Grade Endometrial Stromal Sarcoma: A Case Report and Review of the Literature.
TL;DR: An extremely rare endometrial collision tumor with unusual pathologic features and clinical presentations is revealed in a 48 year-old woman who presented with a large abdominal mass for about 10 years and passed away a month later due to medical complications.
Journal ArticleDOI
Endometrial stromal sarcoma in combination with mixed type endometrial carcinomas: A case report and literature review.
TL;DR: A case of ESS in combination with MT-ECs in a 47-year-old premenopausal woman is described, which presented an overview of the literature and discussed a number of histological and clinical issues.
Journal ArticleDOI
Vaginal endometrial stromal sarcoma: A literature review.
TL;DR: Treatment of VESS incorporates surgery, chemotherapy, radiotherapy, and hormonal therapy, and its prognostic factors may include tumor stage and the expression of hormonal receptors.
Journal ArticleDOI
When the endometrioid adenocarcinoma and the endometrial stromal sarcoma meet: A report of an extremely rare case
Antonios Koutras,Athina A Samara,Thomas Ntounis,Zacharias Fasoulakis,Prokopis Andreas Zotos,S Pittokopitou,Athanasios Pagkalos,S. Moraitis,K Goula,Sotirios K. Sotiriou,Emmanuel N Kontomanolis +10 more
TL;DR: A 49-year-old postmenopausal female with abnormal vaginal bleeding and abdominal pain was diagnosed with two coexistent tumors, a grade 1 endometrioid carcinoma and a pT2 undifferentiated stromal sarcoma (USS) as discussed by the authors .
References
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Journal ArticleDOI
Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?
TL;DR: Data confirm that the carcinomatous element is the "driving force" and that the sarcomatous component is derived from the carcinoma or from a stem cell that undergoes divergent differentiation, and uterine carcinosarcomas are best regarded as metaplastic carcinomas, although the designation carcino-sarcoma is likely to remain.
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Low-grade endometrial stromal sarcoma: hormonal aspects☆
TL;DR: The results suggest that ERT may be detrimental in patients with low-grade endometrial stromal sarcoma and that progestin therapy should be routinely considered for adjuvant therapy and for the treatment of recurrent endometri stromale sarcomas.
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A multi-institutional review of outcomes of endometrial stromal sarcoma
Charles A. Leath,Warner K. Huh,Johnny Hyde,David E. Cohn,Kimberly Resnick,Nicholas P. Taylor,Matthew A. Powell,David G. Mutch,William H. Bradley,Melissa A. Geller,Peter A. Argenta,Michael A. Gold +11 more
TL;DR: Low-grade and high-grade endometrial stromal sarcomas represent two distinct clinical entities and should be treated as such and the need for aggressive cytoreduction is suggested.
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Endometrial stromal sarcoma: analysis of treatment failures and survival.
Angiolo Gadducci,Enrico Sartori,Fabio Landoni,Paolo Zola,Tiziano Maggino,Alessandro Urgesi,Andrea Lissoni,Giuseppe Losa,Antonio Fanucchi +8 more
TL;DR: Low-grade and high-grade endometrial stromal sarcomas have a completely different biological aggressiveness and clinical behavior.
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Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement
Cheng-Han Lee,Rola H. Ali,Marjan Rouzbahman,Adrián Mariño-Enríquez,Meijun Zhu,Xiangqian Guo,Alayne L. Brunner,Sarah Chiang,Samuel Leung,Nataliya Nelnyk,David G. Huntsman,C. Blake Gilks,Torsten O. Nielsen,Paola Dal Cin,Matt van de Rijn,Esther Oliva,Jonathan A. Fletcher,Marisa R. Nucci +17 more
TL;DR: It is indicated that cyclin D1 is a sensitive and specific diagnostic immunomarker for YWHAE-FAM22 ESS and can be included in the immunohistochemical panel when evaluating high-grade uterine sarcomas.