Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Atul Goyal,Nutan Pal,Matthew Concannon,Matthew Paul,Mike Doran,Chiara Poluzzi,Kiyotoshi Sekiguchi,John M. Whitelock,Thomas Neill,Renato V. Iozzo +9 more
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TLDR
It is demonstrated that both perlecan and endorepellin bind directly and with high affinity to both VEGF receptors 1 and 2, in a region that differs from VEGFA-binding site, and hypothesized that a mechanism such as dual receptor antagonism could operate for other angiostatic fragments.About:
This article is published in Journal of Biological Chemistry.The article was published on 2011-07-22 and is currently open access. It has received 98 citations till now. The article focuses on the topics: Vascular endothelial growth factor A & Perlecan.read more
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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more
TL;DR: The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants and is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
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The nature and biology of basement membranes.
TL;DR: Developmental, structural and biochemical aspects of basement membranes are addressed and some of the pathogenetic mechanisms causing diseases linked to abnormal basement membrane diseases are discussed.
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Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
Nikos K. Karamanos,Nikos K. Karamanos,Zoi Piperigkou,Zoi Piperigkou,Achilleas D. Theocharis,Hideto Watanabe,Marco Franchi,Stéphanie Baud,Stéphane Brézillon,Martin Götte,Alberto Passi,Davide Vigetti,Sylvie Ricard-Blum,Ralph D. Sanderson,Thomas Neill,Renato V. Iozzo +15 more
TL;DR: The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.
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Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.
TL;DR: This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.
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Extracellular matrix: The driving force of mammalian diseases.
TL;DR: The ability to understand and modulate matrix-related mechanisms may lead to the future discovery of novel therapeutic options for patients with human malaises including connective tissue disorders, muscular dystrophy, fibrosis, and cancer.
References
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TL;DR: Neither the receptor-associated activity of phosphatidylinositol 3'-kinase nor tyrosine phosphorylation of phospholipase C-gamma were affected by stimulation of Flt1 or KDR expressing cells, and phosphorylated of GTPase activating protein was only slightly increased.
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Matrix Proteoglycans: From Molecular Design to Cellular Function
TL;DR: The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions and additional roles, derived from studies of mutant animals, indicate that certain proteoglycans are essential to life whereas others might be redundant.
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Heparan sulphate proteoglycans fine-tune mammalian physiology
TL;DR: Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices, which affects metabolism, transport, information transfer, support and regulation in all organ systems.