Endothelial Cell Sensing of Flow Direction
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Cites methods from "Endothelial Cell Sensing of Flow Di..."
...78 10 3 Pa s was used for culture medium at 37 C (Wang et al., 2013)....
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...The flow rate and the shear stress were derived from the velocity results. m¼ 0.78 10 3 Pa s was used for culture medium at 37 C (Wang et al., 2013)....
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372 citations
Cites result from "Endothelial Cell Sensing of Flow Di..."
...This in vivo result fits well with an in vitro study showing that flow perpendicular to the morphological and cytoskeletal axis of ECs activated inflammatory pathways, whereas flow that was parallel was antiinflammatory, even if it reversed direction (54)....
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References
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"Endothelial Cell Sensing of Flow Di..." refers background in this paper
...The balance between NO and reactive oxygen species is a major determinant of endothelial function versus dysfunction and atherosclerotic progression in arteries.(49,50) We therefore measured their levels in cells on the micropatterned substrates....
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"Endothelial Cell Sensing of Flow Di..." refers result in this paper
...Similar results for eNOS and Akt are consistent with the known role of Akt upstream of eNOS S1177....
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...Similar results for eNOS and Akt are consistent with the known role of Akt upstream of eNOS S1177.(47) In contrast, NF-κB activation, assessed by phosphorylation of p65 on Ser 536, was activated by lower angles, being maximal at 90° but unchanged after flow reversal (ie, 180°; Figure 2)....
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"Endothelial Cell Sensing of Flow Di..." refers background in this paper
...For example, shear stress at the side walls of the proximal internal carotid artery changes direction sharply during systole over a range of 70°.(33) Formation of aneurysms after repair of aortic coarctation and the distal anastomotic intimal hyperplasia of vascular bypass grafts also correlate strongly with shear stresses...
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