Enhanced camptothecin production by ethanol addition in the suspension culture of the endophyte, Fusarium solani
Citations
167 citations
Cites background from "Enhanced camptothecin production by..."
...Addition of pure and ethanolic extract to the cultures of F. solani enhanced CPT production by 15.5 and 10.6-fold respectively (Venugopalan and Srivastava 2015)....
[...]
164 citations
107 citations
Cites background from "Enhanced camptothecin production by..."
...roseus containing strictosidine as a precursor in CPT biosynthesis, and even by ethanol itself [287]....
[...]
61 citations
Cites background from "Enhanced camptothecin production by..."
...5-fold increase in CPT production was reported in the suspension culture of a CPT producing endophyte, Fusarium solani, using ethanol as an elicitor (Venugopalan and Srivastava 2015)....
[...]
...A 15.5-fold increase in CPT production was reported in the suspension culture of a CPT producing endophyte, Fusarium solani, using ethanol as an elicitor (Venugopalan and Srivastava 2015)....
[...]
60 citations
References
1,437 citations
645 citations
"Enhanced camptothecin production by..." refers background in this paper
...The plant is an ornamental shrub which grows like a weed in the tropics and is the source of about 130 different monoterpene indole alkaloids (but not CPT), all of which use strictosidine as a precursor (van Der Heijden et al., 2004)....
[...]
383 citations
"Enhanced camptothecin production by..." refers methods in this paper
...For extraction of CPT from the biomass, a protocol reported by Puri et al. (2005) was adopted for the study....
[...]
...The amount of CPT present in the sample was estimated on a high performance liquid chromatography instrument (Shimadzu Corporation, Japan) using the protocol suggested by Puri et al. (2005)....
[...]
346 citations
254 citations
"Enhanced camptothecin production by..." refers background in this paper
...The endophytic fungal strain used in the present study was, F. solani MTCC 9668 (Shweta et al., 2010), procured from Microbial Type Culture Collection and GenBank, Chandigarh, India....
[...]
...It is a highly effective anti-cancer molecule as it acts by binding to the topoisomerase I-DNA complex in cancer cells, thus preventing DNA replication and triggering cell death (Shweta et al., 2010)....
[...]