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Journal ArticleDOI

Enhanced sunlight photocatalytic activity and biosafety of marine-driven synthesized cerium oxide nanoparticles.

19 Jul 2021-Scientific Reports (Nature Publishing Group)-Vol. 11, Iss: 1, pp 14734
TL;DR: In this article, the authors present the biosynthesis, physiochemical properties, toxicity and photocatalytic activity of biogenic CeO2 NPs using marine oyster extract as an effective and rich source of bioreducing and capping/stabilizing agents in a one-pot recipe.
Abstract: This contribution presents the biosynthesis, physiochemical properties, toxicity and photocatalytic activity of biogenic CeO2 NPs using, for the first time, marine oyster extract as an effective and rich source of bioreducing and capping/stabilizing agents in a one-pot recipe. CeO2 NPs formation was initially confirmed through the color change from light green to pale yellow and subsequently, their corresponding absorption peak was spectroscopically determined at 310 nm with an optical band-gap of 4.67 eV using the DR-UV technique. Further, XRD and Raman analyses indicated that nanoceria possessed face-centered cubic arrangements without any impurities, having an average crystallite size of 10 nm. TEM and SEM results revealed that biogenic CeO2 NPs was approximately spherical in shape with a median particle size of 15 ± 1 nm. The presence of various bioorganic substances on the surface of nanoparticles was deduced by FTIR and TGA results. It is found that marine-based nanoceria shows no cytotoxic effect on the normal cell, thus indicating their enhanced biocompatibility and biosafety to living organisms. Environmentally, due to energy band gap, visible light-activated CeO2 nanocatalyst revealed superior photocatalytic performance on degradation of methylene blue pollutant with removal rate of 99%. Owing to the simplicity, cost-effectiveness, and environmentally friendly nature, this novel marine biosynthetic route paves the way for prospective applications of nanoparticles in various areas.
Citations
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Journal ArticleDOI
TL;DR: In this paper , the green synthesis of silver nanoparticles (AgNPs) through the use of aqueous Citrus limon zest extract, optimizing the different experimental factors required for the formation and stability of AgNPs was confirmed by the observation of the color change of the mixture of silver nitrate, after the addition of the plant extract.
Abstract: The current work concentrated on the green synthesis of silver nanoparticles (AgNPs) through the use of aqueous Citrus limon zest extract, optimizing the different experimental factors required for the formation and stability of AgNPs. The preparation of nanoparticles was confirmed by the observation of the color change of the mixture of silver nitrate, after the addition of the plant extract, from yellow to a reddish-brown colloidal suspension and was established by detecting the surface plasmon resonance band at 535.5 nm, utilizing UV-Visible analysis. The optimum conditions were found to be 1 mM of silver nitrate concentration, a 1:9 ratio extract of the mixture, and a 4 h incubation period. Fourier transform infrared spectroscopy spectrum indicated that the phytochemicals compounds present in Citrus limon zest extract had a fundamental effect on the production of AgNPs as a bio-reducing agent. The morphology, size, and elemental composition of AgNPs were investigated by zeta potential (ZP), dynamic light scattering (DLS), SEM, EDX, X-ray diffraction (XRD), and transmission electron microscopy (TEM) analysis, which showed crystalline spherical silver nanoparticles. In addition, the antimicrobial and antioxidant properties of this bioactive silver nanoparticle were also investigated. The AgNPs showed excellent antibacterial activity against one Gram-negative pathogens bacteria, Escherichia coli, and one Gram-positive bacteria, Staphylococcus aureus, as well as antifungal activity against Candida albicans. The obtained results indicate that the antioxidant activity of this nanoparticle is significant. This bioactive silver nanoparticle can be used in biomedical and pharmacological fields.

49 citations

Journal ArticleDOI
TL;DR: In this article, the authors used Phlomis leaf extract as an effective reducing agent to synthesize zinc oxide nanoparticles (ZnO NPs) for green nanoparticle synthesis and characterization by UV-Vis spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic light scattering (DLS), Zeta potential, and Field Emission Scanning Electron Microscope (FESEM) techniques.
Abstract: Green nanoparticle synthesis is an environmentally friendly approach that uses natural solvents. It is preferred over chemical and physical techniques due to the time and energy savings. This study aimed to synthesize zinc oxide nanoparticles (ZnO NPs) through a green method that used Phlomis leaf extract as an effective reducing agent. The synthesis and characterization of ZnO NPs were confirmed by UV-Vis spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic light scattering (DLS), Zeta potential, and Field Emission Scanning Electron Microscope (FESEM) techniques. In vitro cytotoxicity was determined in L929 normal fibroblast cells using MTT assay. The antibacterial activity of ZnO nanoparticles was investigated using a disk-diffusion method against S. aureus and E. coli, as well as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) content concentrations. XRD results confirmed the nanoparticles’ crystalline structure. Nanoparticle sizes were found to be around 79 nm by FESEM, whereas the hydrodynamic radius of nanoparticles was estimated to be around 165 ± 3 nm by DLS. FTIR spectra revealed the formation of ZnO bonding and surfactant molecule adsorption on the surface of ZnO NPs. It is interesting to observe that aqueous extracts of Phlomis leave plant are efficient reducing agents for green synthesis of ZnO NPs in vitro, with no cytotoxic effect on L929 normal cells and a significant impact on the bacteria tested.

48 citations

Journal ArticleDOI
TL;DR: An overview of recent developments in green ZnO NP synthesis is presented, emphasizing plant parts as reducing agents and their medical applications, including their antimicrobial, anticancer, antioxidant, and anti-inflammatory properties, as well as key mechanisms of action for these applications to facilitate further research on the biomedical fields in the future.
Abstract: Compared to traditional physical and chemical approaches, nanobiotechnology and plant-based green synthesis procedures offer significant advantages, as well as having a greater range of medical and biotechnological applications. Nanoparticles of zinc oxide (ZnO NPs) have recently been recognized as a promising option for many industries, including optics, electrics, packaged foods, and medicine, due to their biocompatibility, low cytotoxicity, and cost-effectiveness. Several studies have shown that zinc ions are important in triggering cell apoptosis by promoting the generation of reactive oxygen species (ROSs) and releasing zinc ions (Zn2+), which are toxic to cells. The toxic nature of the chemicals used in the synthesis of ZnO nanoparticles limits their clinical utility. An overview of recent developments in green ZnO NP synthesis is presented in this review, emphasizing plant parts as reducing agents and their medical applications, including their antimicrobial, anticancer, antioxidant, and anti-inflammatory properties, as well as key mechanisms of action for these applications to facilitate further research on the biomedical fields in the future.

25 citations

Journal ArticleDOI
TL;DR: In this article , a multifunctional Fe 3+ /Gd 3+ -CeO 2 @RGO (FGC@RGO) nanohybrid was synthesized via facile co-precipitation and ultra-sonication methods.

17 citations

Journal ArticleDOI
TL;DR: In this paper , a one-step and facile hydrothermal procedure was introduced for the first time to synthesize nickel(II) oxide (NiO) nanoparticles, which were used as high efficient, low toxic and cost catalyst for the synthesis of some organic compounds.
Abstract: The present work introduces a one-step and facile hydrothermal procedure as a green process for the first time to synthesize nickel(II) oxide (NiO) nanoparticles. The as-prepared nanomaterials were used as high efficient, low toxic and cost catalyst for the synthesis of some organic compounds. Ni(NO3)2 and some natural extract were used as a surfactant for the first time to synthesis NiO nanomaterials. A high synthesis yield (91%) was obtained for S2. Rietveld analysis affirmed the cubic crystal system of the obtained NiO nanocatalyst. The morphology studies were carried out with the FESEM method and the images revealed a change from non-homogenous to homogenous spherical particles when the Barberryas was used instead of orange blossom surfactant. Besides, the images revealed that the particle size distribution was in the range of 20 to 60 nm. The synthesized catalysts were used for the first time in Biginelli multicomponent reactions (MCRs) for the preparation of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) under the present facile reaction conditions. High yield (97%) of the final product was achieved at the optimum condensation reaction conditions (Catalyst: 60 mg; temperature: 90 °C and time: 90 min) when ethyl acetoacetate/methyl acetoacetate (1 mmol), benzaldehyde (1 mmol) and urea (1.2 mmol) were used. A kinetic study affirmed pseudo-first-order model for Biginelli reactions followed the pseudo-first-order model.

12 citations

References
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Journal ArticleDOI
TL;DR: In situ click chemistry is used to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity, significantly higher than that of widely used selective cyclooxygenase-2 inhibitors.
Abstract: Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases. The amino-acid sequence and structural similarity between inducible cyclooxygenase-2 and housekeeping cyclooxygenase-1 isoforms present a significant challenge to design selective cyclooxygenase-2 inhibitors. Herein, we describe the use of the cyclooxygenase-2 active site as a reaction vessel for the in situ generation of its own highly specific inhibitors. Multi-component competitive-binding studies confirmed that the cyclooxygenase-2 isozyme can judiciously select most appropriate chemical building blocks from a pool of chemicals to build its own highly potent inhibitor. Herein, with the use of kinetic target-guided synthesis, also termed as in situ click chemistry, we describe the discovery of two highly potent and selective cyclooxygenase-2 isozyme inhibitors. The in vivo anti-inflammatory activity of these two novel small molecules is significantly higher than that of widely used selective cyclooxygenase-2 inhibitors. Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.

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Journal ArticleDOI
TL;DR: In this article, the authors used sea ice motion retrievals from Sentinel-1 imagery to report on the recent behavior of these ice arches and the associated ice fluxes, and they showed that the duration of arch formation has decreased over the past 20 years, while the ice area and volume fluxes along Nares Strait have both increased.
Abstract: The ice arches that usually develop at the northern and southern ends of Nares Strait play an important role in modulating the export of Arctic Ocean multi-year sea ice. The Arctic Ocean is evolving towards an ice pack that is younger, thinner, and more mobile and the fate of its multi-year ice is becoming of increasing interest. Here, we use sea ice motion retrievals from Sentinel-1 imagery to report on the recent behavior of these ice arches and the associated ice fluxes. We show that the duration of arch formation has decreased over the past 20 years, while the ice area and volume fluxes along Nares Strait have both increased. These results suggest that a transition is underway towards a state where the formation of these arches will become atypical with a concomitant increase in the export of multi-year ice accelerating the transition towards a younger and thinner Arctic ice pack.

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TL;DR: This paper serves as a comprehensive review, where for selected 14 carbohydrates in the solid state both FT-Raman and ATR FT-IR spectra were collected and assigned and marker bands of the studied molecules can be identified and correlated with their structure.

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TL;DR: It was observed that cerium oxide nanoparticles penetrated into the cytoplasm and located in the peri-region of the nucleus as aggregated particles, which may induce the direct interaction between nanoparticles and cellular molecules to cause adverse cellular responses.

551 citations

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TL;DR: The present review targets the comparative biogenic synthesis and mechanisms of nanoparticles using algae and waste materials (agro waste in the presence of biomolecules) and some of the applications of the biosynthesized nanoparticles in biomedical, catalysis and biosensors fields.

522 citations