Open AccessJournal Article
Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum.
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This article showed that mice treated with antilymphocyte serum (ALS) and immunized with type III pneumococcal polysaccharide (SSS-III) showed a tenfold increase in the number of direct splenic plaque-forming cells (PFC); no indirect PFC were detected in such mice.Abstract:
Summary Mice treated with antilymphocyte serum (ALS) and immunized with type III pneumococcal polysaccharide (SSS-III) showed a tenfold increase in the number of direct splenic plaque-forming cells (PFC); no indirect PFC were detected in such mice. These findings suggest that ALS may have selectively eliminated a population of cells which exerts a regulatory effect on the antibody response to SSS-III.read more
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Book ChapterDOI
The regulatory influence of activated T cells on B cell responses to antigen.
David H. Katz,Baruj Benacerraf +1 more
TL;DR: This chapter discusses the intimate mechanisms of the regulation of antibody responses by T cells, the significance of these phenomena for the regulatory processes of the immune system, and their possible implication for the pathogenesis of various immunopathological states.
Book ChapterDOI
T cell control of antibody production.
TL;DR: A second golden age of “thymology” began with the discovery that thymus-derived lymphocytes did not themselves make circulating antibodies, but rather assisted other nonthymUS- derived lymphocytes to do so.
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Biological Expressions of Lymphocyte Activation
Robert R. Rich,Carl W. Pierce +1 more
TL;DR: A population of thymus-derived lymphocytes has been identified that, upon activation by the nonspecific plant mitogen concanavalin A, suppresses the development of plaque-forming cell responses in fresh or 48-h antigen-stimulated cultures of mouse spleen cells.
Journal ArticleDOI
Suppressor T-cell abnormality in idiopathic systemic lupus erythematosus.
Nabih I. Abdou,Nabih I. Abdou,Akira Sagawa,Akira Sagawa,Elisio Pascual,Elisio Pascual,Jacques Hebert,Jacques Hebert,Saeed Sadeghee,Saeed Sadeghee +9 more
TL;DR: There was a significant correlation between disease activity and the degree of suppression of SLE-B cells by the T cells of normals, suggesting the emergence of autoreactive clones and hyperfunction of B cells could be secondary to suppressor T-cell deficiency or dysfunction in SLE.
Journal ArticleDOI
Evidence for thymus-independent humoral antibody production in mice against polyvinylpyrrolidone and E. coli lipopolysaccharide
Birger Andersson,Henric Blomgren +1 more
TL;DR: It is concluded that thymus cells do not act as antigen-concentrating cells and that they play no detectable role for humoral antibody formation in the systems here examined, and that E. coli LPS could specifically enhance the antibody response of thymectomized mice against antigen-coated sheep erythrocytes.
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