Enhancing the bioavailability of resveratrol by combining it with piperine.
Citations
509 citations
Cites methods from "Enhancing the bioavailability of re..."
...[88] used piperine, an alkaloid derived from black pepper, in vivo to inhibit glucuronidation, and observed a 1544% increase in the maximum serum resveratrol concentration, a 229% enhancement of the area under the concentration curve expressing the degree of exposure to resveratrol, and a two-fold increase in Tmax after single oral administration in healthy mice....
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459 citations
Cites background from "Enhancing the bioavailability of re..."
...Resveratrol’s poor bioavailability is a significant issue with regard to extrapolating its effects to humans, and various approaches have been created to enhance its bioavailability [311], including consuming it with various foods [312], using it in combination with an additional phytochemical piperine [313], and using a prodrug approach [314], micronized powders [315,316], or nanotechnological formulations [317–319]....
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422 citations
Cites background from "Enhancing the bioavailability of re..."
...In mice, piperine significantly increased the serum levels of resveratrol after oral administration of both compounds (Johnson et al. 2011)....
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391 citations
Cites background from "Enhancing the bioavailability of re..."
...Other more specific strategies previously approached in animals such as the inhibition of CYPs by using known inhibitors like piperine [320] are also under evaluation in humans (Supplementary Table 11)....
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283 citations
Cites background or result from "Enhancing the bioavailability of re..."
...This conclusion was further validated after Zheng and colleagues in a study of prostate cancer in the Asian population [59]....
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...Pharmacokinetic evidence indicate that resveratrol has poor bioavailability due to its rapid and extensive liver metabolism which severely impairs its therapeutic effects [58, 59]....
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...Several approaches, with variable results, have been attempted to overcome this problem [60], including combining resveratrol with glucuronidation inhibitors such as piperine [59], developing resveratrol nanoparticles [61, 62], and utilizing novel drug delivery systems to protect and stabilize resveratrol to enhance its bioavailability [63, 64]....
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References
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"Enhancing the bioavailability of re..." refers background in this paper
...The phenomenon of ‘‘French Paradox’’, the observation that French people suffer a relatively low incidence of coronary heart disease (despite having a diet relatively rich in saturated fats), has been attributed to the consumption of red wine that contains resveratrol [6]....
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1,599 citations
1,577 citations
"Enhancing the bioavailability of re..." refers background in this paper
...Interestingly, in our study, we observed the presence of a second peak in serum with the resveratrol metabolite, which may be explained by enterohepatic recirculation of resveratrol, which has been observed in rats and humans [20, 27]....
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...Studies in healthy human volunteers have shown that resveratrol is rapidly absorbed but quickly metabolized, usually within 30–60 min following oral or intravenous administration in humans [10, 20]....
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1,493 citations