Journal ArticleDOI
Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency
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This article is published in American Journal of Physiology-cell Physiology.The article was published on 1978-09-01. It has received 763 citations till now. The article focuses on the topics: Thyroid & Propylthiouracil.read more
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Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary
Michael Berelowitz,Marta Szabo,Lawrence A. Frohman,Susan Firestone,Lily Chu,Raymond L. Hintz +5 more
TL;DR: It is suggested that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary.
Journal ArticleDOI
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
Brian K. Kobilka,Hiroaki Matsui,Tong Sun Kobilka,Teresa L. Yang-Feng,Uta Francke,Marc G. Caron,Robert J. Lefkowitz,John W. Regan +7 more
TL;DR: The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor, and two related genes have been identified by low stringency Southern blot analysis.
Journal ArticleDOI
Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity
Brian K. Kobilka,Tong Sun Kobilka,Kiefer W. Daniel,John W. Regan,Marc G. Caron,Robert J. Lefkowitz +5 more
TL;DR: The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects on the adenylyl cyclase system.
Journal ArticleDOI
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
Laura Lasagni,Michela Francalanci,Francesco Annunziato,Elena Lazzeri,Stefano Giannini,Lorenzo Cosmi,Costanza Sagrinati,Benedetta Mazzinghi,Claudio Orlando,Enrico Maggi,Fabio Marra,Sergio Romagnani,Mario Serio,Paola Romagnani +13 more
TL;DR: A distinct, previously unrecognized receptor named CXCR3-B is described, derived from an alternative splicing of the CX CR3 gene that mediates the angiostatic activity of CxCR3 ligands and also acts as functional receptor for CXCL4.
Journal ArticleDOI
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
TL;DR: The data support the proposal that enhancement of penile erection by sildenafil in patients with erectile dysfunction involves potentiation of the NO-stimulated cGMP signal mediating relaxation of cavernosal smooth muscle during sexual stimulation.
References
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Journal ArticleDOI
ATPase Activity of Myosin Correlated with Speed of Muscle Shortening
TL;DR: A role for the ATPase activity of myosin in determining the speed of muscle contraction is suggested and the F-actin-binding ability of myOSin from various muscles was rather constant.
Book ChapterDOI
[1] Citrate synthase. [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]
TL;DR: This chapter is dedicated to describing citrate synthase, which can be followed by measuring the appearance of the free SH group of the released CoASH through three methods discussed in the chapter.
Journal ArticleDOI
Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits.
Journal ArticleDOI
Dynamic properties of fast and slow skeletal muscles of the rat during development.
TL;DR: It will be shown that at any stage of development the ratio of the twitch contraction times of fast and slow muscles is approximately equal to the inverse ratio of their speeds of shortening, leading to the view that the duration of the active state is inversely proportional to the speed of longening of the contractile material.
Journal ArticleDOI
Significance of impulse activity in the transformation of skeletal muscle type
TL;DR: The changes which follow cross reinnervation of mammalian fast and slow twitch muscles may reflect a capacity of skeletal muscle to respond adaptively to different functional requirements.
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Ligand: a versatile computerized approach for characterization of ligand-binding systems.
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