Enzyme Therapy: Current Challenges and Future Perspectives.
Miguel de la Fuente,Laura Lombardero,Alfonso Gomez-Gonzalez,Cristina Solari,Iñigo Angulo-Barturen,Arantxa Acera,Elena Vecino,Egoitz Astigarraga,Gabriel Barreda-Gómez +8 more
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In this article, the angiotensin-converting enzyme 2 (ACE2) is used to treat COVID-19, which can convert a wide range of target molecules to restore the correct physiological metabolism.Abstract:
In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular diseases. Treatments based on the catalytic activity of enzymes are able to convert a wide range of target molecules to restore the correct physiological metabolism. These treatments present several advantages compared to established therapeutic approaches thanks to their affinity and specificity properties. However, enzymes present some challenges, such as short in vivo half-life, lack of targeted action and, in particular, patient immune system reaction against the enzyme. For this reason, it is important to monitor serum immune response during treatment. This can be achieved by conventional techniques (ELISA) but also by new promising tools such as microarrays. These assays have gained popularity due to their high-throughput analysis capacity, their simplicity, and their potential to monitor the immune response of patients during enzyme therapies. In this growing field, research is still ongoing to solve current health problems such as COVID-19. Currently, promising therapeutic alternatives using the angiotensin-converting enzyme 2 (ACE2) are being studied to treat COVID-19.read more
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Bioactive material-based nanozymes with multifunctional attributes for biomedicine: Expanding antioxidant therapeutics for neuroprotection, cancer, and anti-inflammatory pathologies
D. O. Lopez-Cantu,Reyna Berenice González-González,Ashutosh Sharma,Muhammad Bilal,Roberto Parra-Saldívar,Hafiz M.N. Iqbal +5 more
TL;DR: In this article , the authors provide a biochemical rationale in the context of antioxidant nano-enzymes and present an overview of the recent advances in nanozymes as possible therapeutic agents.
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Artificial Cells: Past, Present and Future.
TL;DR: Artificial cells are used as carriers for materials and information exchange and have been shown to function as targeted delivery systems of personalized drugs and to substitute for cells with impaired function.
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Liposomes as Tools to Improve Therapeutic Enzyme Performance
TL;DR: This review will focus on enzymes with therapeutic properties and their applications, listing some that reached the pharmaceutical market, with special attention being paid to liposomes, the most well-studied and suitable nanosystem for enzyme delivery in vivo.
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Elevation of Tear MMP-9 Concentration as a Biomarker of Inflammation in Ocular Pathology by Antibody Microarray Immunodetection Assays
M. de la Fuente,Iñaki Rodriguez-Agirretxe,Elena Vecino,Egoitz Astigarraga,Arantxa Acera,Gabriel Barreda-Gómez +5 more
TL;DR: It is demonstrated that the AbMAs system allows the quantification of MMP-9 in pathologies that involve inflammation of the ocular surface.
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Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections
TL;DR: In this article , the potential of enzymes, in particular, polysaccharide degrading enzymes, for biofilm dispersion, which might lead to facile antimicrobial treatment of biofilm-associated infections.
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