Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults
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Cites background from "Epicutaneous immunotherapy for the ..."
...Epicutaneous 6 immunotherapy (EPIT) is also under investigation for peanut and milk; it involves application 7 of patches containing food allergen onto the skin (17)....
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...A single 27 prospective RCT of EPIT with peanut suggests a favorable safety profile (17)....
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...This effect was higher in patients below 11 years of 26 age (17)....
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"Epicutaneous immunotherapy for the ..." refers background in this paper
...5% to 1%(1,2) and a 3fold increase noted from 1997-2008.(2) In addition to being a key culprit in food-induced mortality, peanut allergy is associated with reduced quality of life and health economic effect....
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643 citations
"Epicutaneous immunotherapy for the ..." refers background or result in this paper
...In comparison, OIT is associated with more adverse reactions, including anaphylaxis, but has been shown to induce robust changes in challenge thresholds of 5,000 to 10,000 mg.(9,11,14,21,33,34) Sublingual immunotherapy is associated with fewer adverse reactions than OIT, but changes in challenge SCD are also more modest, with our CoFAR study of a similar design demonstrating a change in SCD of approximately 500 mg....
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...The immunomodulation noted with active treatment, including increases in peanut-specific IgG4 levels and IgG4/IgE ratios, is consistent with changes seen with other forms of food immunotherapy.(11,14,33-36) The trends seen in both basophil and Tcell responses suggest that exposure to peanut through intact skin might modulate TH2 responses and basophil reactivity....
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...Oral immunotherapy (OIT) has been shown to induce desensitization inmost participants and sustained unresponsiveness in a minority, although adverse reactions are common.(9,11,14,20-22) Epicutaneous immunotherapy (EPIT) is an emerging modality for the treatment of food allergy....
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562 citations