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Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
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Dengue fever/dengue hemorrhagic fever is now one of the most important public health problems in tropical developing countries and also has major economic and societal consequences.About:
This article is published in Trends in Microbiology.The article was published on 2002-02-01. It has received 1494 citations till now. The article focuses on the topics: 2009 Bolivian dengue fever epidemic & Dengue fever.read more
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Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses
TL;DR: Three examples of emerging and resurging diseases of global significance are described: the resurgence of dengue in tropical and subtropical areas of the world, and the spread and establishment of Japanese encephalitis and West Nile viruses in new habitats and environments.
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A structural perspective of the flavivirus life cycle
TL;DR: The structural organization of these viruses and their associated structural proteins has provided insight into the molecular transitions that occur during the viral life cycle, such as assembly, budding, maturation and fusion.
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A Ligand-Binding Pocket in the Dengue Virus Envelope Glycoprotein.
TL;DR: A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion, which points to a structural pathway for the fusion-activating transition and suggests a strategy for finding small-molecule inhibitors of d Dengue and other flaviviruses.
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The Global Emergence/Resurgence of Arboviral Diseases As Public Health Problems
TL;DR: The factors responsible for the dramatic resurgence of arboviral Diseases in the waning years of the 20th century are discussed, as is the need for rebuilding the public health infrastructure to deal with epidemic vector-borne diseases in the 21st century.
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Composition and three-dimensional architecture of the dengue virus replication and assembly sites.
Sonja Welsch,Sven Miller,Inés Romero-Brey,Andreas Merz,Christopher K. E. Bleck,Paul Walther,Stephen D. Fuller,Claude Antony,Jacomine Krijnse-Locker,Ralf Bartenschlager +9 more
TL;DR: Dengue virus (DENV) modifies ER membrane structure to promote replication and efficient encapsidation of the genome into progeny virus, which could explain the coordination of distinct steps of the flavivirus replication cycle.
References
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Dengue and Dengue Hemorrhagic Fever
TL;DR: A review of the changing epidemiology of dengue and hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both Dengue fever and DVF, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control can be found in this paper.
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Dengue and dengue hemorrhagic fever
TL;DR: Control of dengue at the present time is dependent on control of the principal vector mosquito, A. aegypti, and indigenous transmission in the continental United States remains a public health concern.
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Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas.
Rebeca Rico-Hesse,Lisa M. Harrison,Rosa Alba Salas,Duilia Tovar,Ananda Nisalak,Celso Ramos,Jorge Boshell,Maria Teresa R. de Mesa,Rita Maria Ribeiro Nogueira,Amelia P.A. Travassos Da Rosa +9 more
TL;DR: Phylogenetic analyses suggest that these genotypes of dengue type 2 virus originated in Southeast Asia and that they displaced the native, American genotype in at least four countries, and vaccination and other control efforts should therefore be directed at decreasing the transmission of these "virulent" genotypes.
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Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up
TL;DR: It is a great honor to be asked to present the Charles Franklin Craig Lecture of this Society and to express his sincere thanks to those responsible for his selection as the Craig lecturer, including the committee who selected me for this honor.
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