Epidemiological and laboratory characterization of a yellow fever outbreak in northern Uganda, October 2010–January 2011
Joseph F. Wamala,Mugagga Malimbo,Charles Okot,Ann D. Atai-Omoruto,Emmanuel Tenywa,Jeffrey R. Miller,Stephen Balinandi,Trevor Shoemaker,Charles Oyoo,Emmanuel O. Omony,Atek Kagirita,Monica Musenero,Issa Makumbi,Miriam Nanyunja,Julius J. Lutwama,Robert Downing,Anthony K. Mbonye +16 more
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TLDR
The wide geographical case dispersion as well as the male and older age preponderance suggests transmission during the yellow fever outbreak was largely sylvatic and related to occupational activities around forests.About:
This article is published in International Journal of Infectious Diseases.The article was published on 2012-07-01 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Outbreak & Attack rate.read more
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Immune activation alters cellular and humoral responses to yellow fever 17D vaccine
Enoch Muyanja,Aloysius Ssemaganda,Pearline Ngauv,Rafael Cubas,Helene Perrin,Divya Srinivasan,Glenda Canderan,Benton Lawson,Jakub Kopycinski,Amanda S. Graham,Dawne K. Rowe,Michaela J. Smith,Denis Gaucher,Sharon Isern,Scott F. Michael,Guido Silvestri,Thomas H. Vanderford,Erika Castro,Giuseppe Pantaleo,Joel Singer,Jill Gillmour,Noah Kiwanuka,Noah Kiwanuka,Annet Nanvubya,C. Schmidt,Josephine Birungi,Josephine H. Cox,Elias K. Haddad,Pontiano Kaleebu,Pontiano Kaleebu,Patricia E. Fast,Rafick Pierre Sekaly,Lydie Trautmann +32 more
TL;DR: It is demonstrated that an activated immune microenvironment prior to vaccination impedes efficacy of the YF-17D vaccine in an African cohort and suggest that vaccine regimens may need to be boosted in African populations to achieve efficient immunity.
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Next-Generation Sequencing for Infectious Disease Diagnosis and Management: A Report of the Association for Molecular Pathology
TL;DR: Although NGS holds enormous promise for clinical infectious disease testing, many challenges remain, including automation, standardizing technical protocols and bioinformatics pipelines, improving reference databases, establishing proficiency testing and quality control measures, and reducing cost and turnaround time, all of which would be necessary for widespread adoption of NGS in clinical microbiology laboratories.
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Ebola viral hemorrhagic disease outbreak in West Africa- lessons from Uganda
TL;DR: Uganda's experience in controlling similar Ebola outbreaks and some lessons that could inform the control of the Ebola outbreak in West Africa are shared to draw some lessons from the Uganda experience and adapt them to contain the Ebola epidemic.
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What Does the Future Hold for Yellow Fever Virus? (II)
Raphaëlle Klitting,Carlo Fischer,Carlo Fischer,Jan Felix Drexler,Jan Felix Drexler,Ernest A. Gould,David Roiz,Christophe Paupy,Xavier de Lamballerie +8 more
TL;DR: The current state of knowledge and gaps regarding the molecular biology and transmission dynamics of YFV are described, along with an overview of the tools that can be used to manage the disease at individual, local and global levels.
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Yellow fever disease: density equalizing mapping and gender analysis of international research output
TL;DR: The present data shows an increase in research productivity over the entire study period, in particular an increase of female scientists, a fact that is confirmed by other studies.
References
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Yellow fever: an update
TL;DR: As a zoonosis, yellow fever cannot be eradicated, but reduction of the human disease burden is achievable through routine childhood vaccination in endemic countries, with a low cost for the benefits obtained.
Book
Principles and Practice of Clinical Virology
TL;DR: The Herpesviridae: Herpes Simplex Varicella Zoster Cytomegalovirus Epstein-Barr Virus Human Herpes Virus 6, 7 Hepatitis Viruses Viruses Associated with Acute Diarrhoeal Disease Respiratory Tract Viruses Influenza Parainfluenza Viruses Respiratories Syncytial Virus Adenoviruses Rhinoviruse Coronaviruses Measles Rubella Mumps Enterovirus Pox
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An outbreak of Ebola in Uganda.
Samuel Okware,F. G. Omaswa,Sam Zaramba,Alex Opio,Julius J. Lutwama,J. Kamugisha,Elly B. Rwaguma,P. Kagwa,M Lamunu +8 more
TL;DR: Uganda was finally declared Ebola free on 27 February 2001, 42 days after the last case was reported, and all levels of the community spontaneously demonstrated solidarity and response to public health interventions.
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Acne: clinical presentations.
TL;DR: There are almost as many classifications of acne as there are clinicians with particular interest in the disease, and the classic textbook definition of a nodule refers to lesions 1 cm or larger, but the early investigators of oral isotretinoin defined nodules as 4 mm or larger.
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Next-generation sequencing and its applications in molecular diagnostics
TL;DR: An overview of four commonly used next-generation sequencing technologies from Roche Applied Science//454 Life Sciences, Illumina, Life Technologies and Helicos Biosciences is provided.