Journal ArticleDOI
Épidémiologie et histoire naturelle de l’artérite à cellules géantes (Horton)
Reads0
Chats0
TLDR
Evidence is mounting that overall mortality in GCA patients is at best slightly higher than expected in relation to general population mortality data, but GCA is associated with an increase in morbidity and mortality specifically related to aortic aneurysm or other cardiovascular causes.Abstract:
Knowledge of the natural history and epidemiology of giant cell arteritis (GCA) is growing. With the recent conceptual change, GCA is no longer considered a disease with mandatory cranial symptoms but, rather, a larger disease spectrum also including idiopathic aortitis in people older than 50 and polymyalgia rheumatica with large-vessel involvement. The incidence peak between age 70 and 80 years, greater frequency in females and greater occurrence in Nordic countries are well-established epidemiological characteristics. Conversely, the notion that the incidence of GCA is increasing is challenged by several recent population-based studies suggesting a trend reversal for about 15 to 20 years. The known link with the allele HLA-DRB1*04 was confirmed by a genome-wide association study that also found associations with two other genetic polymorphisms. Recent studies indicating a link with varicella zoster virus infection have invigorated the hypothesis of an infectious cause for GCA. Smoking is the most solidly recognized environmental risk factor, but other traditional cardiovascular risk factors do not seem to predispose to GCA. Evidence is mounting that overall mortality in GCA patients is at best slightly higher than expected in relation to general population mortality data, but GCA is associated with an increase in morbidity and mortality specifically related to aortic aneurysm or other cardiovascular causes. Further studies are needed to integrate the current knowledge into a single etiological model.read more
Citations
More filters
Journal ArticleDOI
Giant-cell arteritis-related mortality in France: A multiple-cause-of-death analysis.
T. Chazal,Raphael Lhote,Grégoire Rey,Julien Haroche,Mireille Eb,Zahir Amoura,Fleur Cohen Aubart +6 more
TL;DR: In this analysis of French death certificates mentioning GCA, a stable standardized mortality rate between 2005 and 2014 is observed and the most frequent associated diseases were cardiovascular diseases and infections.
Journal ArticleDOI
Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study.
TL;DR: Although this geo-epidemiologic study has potential for aggregation and selection biases, there was no positive biologic gradient between the incidence of clinically evident HZ and GCA.
Journal ArticleDOI
The incidence of giant cell arteritis in Ontario, Canada.
Edsel Ing,Gabriela Lahaie Luna,Christian Pagnoux,P. Baer,Dani Wang,Etienne Benard-Seguin,Ishan Godra,Anita Godra,David G. Munoz,Kylen D McReelis,Martin ten Hove +10 more
TL;DR: The estimated incidence of biopsy-proven giant cell arteritis in Ontario using 2 different estimation techniques was comparable, but low compared with other countries.
Journal ArticleDOI
Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis
Marie Aussedat,Hervé Lobbes,Maxime Samson,Romain Euvrard,Jean-Christophe Lega,Sabine Mainbourg +5 more
TL;DR: In this article, the authors determined the prevalence and incidence of major relapse in GCA using published data and found that the duration of follow-up was negatively associated with the incidence of relapses.
Journal ArticleDOI
Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis
TL;DR: In this paper , the authors determined the prevalence and incidence of major relapse in GCA using published data and found that the duration of follow-up was negatively associated with the incidence of relapses.
References
More filters
Journal ArticleDOI
Epidemiology of giant cell arteritis and polymyalgia rheumatica.
Miguel A. Gonzalez-Gay,Tomas R. Vazquez-Rodriguez,Maria J. Lopez-Diaz,José A. Miranda-Filloy,Carlos González-Juanatey,Javier Martin,Javier Llorca +6 more
TL;DR: Giant cell arteritis and Polymyalgia rheumatica are relatively common diseases in the elderly due to the progressive aging of the population in Western countries.
Journal ArticleDOI
Disease pattern in cranial and large-vessel giant cell arteritis.
TL;DR: Large-vessel GCA was associated with higher concentrations of interleukin-2 gene transcripts in arterial tissue and overrepresentation of the HLA-DRB1*0404 allele, indicating differences in pathogenetic mechanisms.
Journal ArticleDOI
Tissue Cytokine Patterns in Patients with Polymyalgia Rheumatica and Giant Cell Arteritis
TL;DR: In this paper, the authors analyzed temporal artery specimens from patients with giant cell arteritis and polymyalgia rheumatica for the presence of inflammatory cytokines and to ascertain whether a specific cyt...
Journal ArticleDOI
Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis.
Niall E. Roche,James W. Fulbright,Annette D. Wagner,Gene G. Hunder,Jörg J. Goronzy,Cornelia M. Weyand +5 more
TL;DR: The close correlation of plasma IL-6 concentrations with clinical symptoms suggests a direct contribution of this cytokine to the disease manifestations and presents the possibility that monitoring IL- 6 levels would be useful in making decisions on adjustment of corticosteroid dosage in individual patients.
Journal ArticleDOI
Incidence of diagnosed polymyalgia rheumatica and temporal arteritis in the United Kingdom, 1990–2001
TL;DR: Both PMR and TA were more common in the south than in the north of the UK, and both were more commonly diagnosed in the summer months, which may be partly attributable to a risk factor which is more prevalent in theSouth and east of the United Kingdom.