Journal ArticleDOI
Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy
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TLDR
Determinants of pre-eclampsia rates include a bewildering array of risk and protective factors, including familial factors, sperm exposure, maternal smoking, pre-existing medical conditions (such as hypertension, diabetes mellitus and anti-phospholipid syndrome), and miscellaneous ones such as plurality, older maternal age and obesity.Abstract:
Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, pre-eclampsia and chronic hypertension with superimposed pre-eclampsia. Pre-eclampsia complicates about 3% of pregnancies, and all hypertensive disorders affect about five to 10% of pregnancies. Secular increases in chronic hypertension, gestational hypertension and pre-eclampsia have occurred as a result of changes in maternal characteristics (such as maternal age and pre-pregnancy weight), whereas declines in eclampsia have followed widespread antenatal care and use of prophylactic treatments (such as magnesium sulphate). Determinants of pre-eclampsia rates include a bewildering array of risk and protective factors, including familial factors, sperm exposure, maternal smoking, pre-existing medical conditions (such as hypertension, diabetes mellitus and anti-phospholipid syndrome), and miscellaneous ones such as plurality, older maternal age and obesity. Hypertensive disorders are associated with higher rates of maternal, fetal and infant mortality, and severe morbidity, especially in cases of severe pre-eclampsia, eclampsia and haemolysis, elevated liver enzymes and low platelets syndrome.read more
Citations
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Journal ArticleDOI
Preeclampsia: Pathophysiology, Challenges, and Perspectives
Sarosh Rana,Elizabeth R. Lemoine,Elizabeth R. Lemoine,Joey P. Granger,S. Ananth Karumanchi,S. Ananth Karumanchi +5 more
TL;DR: The current evidence for the role of abnormal placentation and therole of placental factors such as the antiangiogenic factor, sFLT1 (soluble fms-like tyrosine kinase 1) in the pathogenesis of the maternal syndrome of preeclampsia is discussed.
Journal ArticleDOI
Pre-eclampsia part 1: current understanding of its pathophysiology
TL;DR: The diagnosis, classification, clinical manifestations and putative pathogenetic mechanisms of pre-eclampsia are discussed.
Journal ArticleDOI
Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease.
Sarka Lisonkova,K.S. Joseph +1 more
TL;DR: Early- and late-onset preeclampsia shares some etiological features, differ with regard to several risk factors, and lead to different outcomes, and should be treated as distinct entities from an etiological and prognostic standpoint.
Journal ArticleDOI
Pre-eclampsia: pathogenesis, novel diagnostics and therapies.
Elizabeth A. Phipps,Elizabeth A. Phipps,Ravi Thadhani,Ravi Thadhani,Thomas Benzing,S. Ananth Karumanchi,S. Ananth Karumanchi +6 more
TL;DR: The pathogenic role of antiangiogenic proteins released by the placenta in the development of pre-eclampsia is discussed and novel therapeutic strategies directed at restoring the angiogenic imbalance observed during pre- eClampsia are reviewed.
Journal ArticleDOI
Hypertensive disorders in pregnancy
Madhusudan Upadya,Sumesh T Rao +1 more
TL;DR: The basic management objectives should be facilitating the birth of an infant who subsequently thrives and completes restoration of health to the mother, or the termination of pregnancy with the least possible trauma to mother and foetus in severe pre-eclampsia.
References
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Journal ArticleDOI
WHO analysis of causes of maternal death: a systematic review
TL;DR: Haemorrhage and hypertensive disorders are major contributors to maternal deaths in developing countries and these data should inform evidence-based reproductive health-care policies and programmes at regional and national levels.
Journal ArticleDOI
Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy
Journal ArticleDOI
Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis
TL;DR: A history of pre-eclampsia should be considered when evaluating risk of cardiovascular disease in women, and this association might reflect a common cause for pre- eClampsia and cardiovascular disease, or an effect ofPre-e Clampsia on disease development, or both.
Journal ArticleDOI
The Global Impact of Pre-eclampsia and Eclampsia
TL;DR: Although it is a low cost effective treatment, magnesium sulfate is not available in all low and middle income countries; scaling up its use for eClampsia and severe preeclampsia will contribute to achieving the Millennium Development Goals.
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