Epidemiology of uterine fibroids: a systematic review
TL;DR: Uterine fibroids are the most common neoplasm affecting women that can cause significant morbidity and may adversely impact fertility.
About: This article is published in British Journal of Obstetrics and Gynaecology.The article was published on 2017-09-01 and is currently open access. It has received 508 citations till now. The article focuses on the topics: Risk factor & Uterine fibroids.
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TL;DR: The recent progress and available management strategies for uterine fibroids are reviewed and areas where further research is needed to find new therapeutic targets and better personalize treatments are highlighted.
199 citations
TL;DR: New sections on the psychological aspects of surgical care (especially in extirpative surgery) and a timely chapter on breast disease are added to this venerable text, the acknowledged standard source for indications and techniques.
Abstract: This venerable text, the acknowledged standard source for indications and techniques, now enters its sixth edition, eight years after the last was published. The page total has increased from 871 to 938. On the cover, John Thompson's name has been added to Richard Mattingly's. The latter has done a superb job over the years of steering this text along the difficult course of including and excluding data. Among the welcome additions are sections on the psychological aspects of surgical care (especially in extirpative surgery) and a timely chapter on breast disease. Although most gynecologists do not perform breast surgery, they can detect more pathological conditions of the breast than other individual specialists because of their role as primary care providers for women. Minor procedures such as office breast cyst aspiration are well detailed. Other sections of the text have been updated, such as the use of staplers for bowel anastomosis.
130 citations
TL;DR: Uterine fibroids affect a wide cross‐section of the population, with prevalence, symptom severity, and overall disease burden generally higher among black women, likely due to both genetic and environmental factors.
Abstract: Uterine fibroids affect a wide cross-section of the population, with prevalence, symptom severity, and overall disease burden generally higher among black women, likely due to both genetic and environmental factors. Potential symptoms of uterine fibroids include painful and excessive uterine bleeding, interference with everyday life and self-image, and impaired fertility. Because of the high estimated prevalence and costs associated with treatments, the direct and indirect costs of uterine fibroids are substantial for both the health care system and the individual patient. Special patient populations—such as black women, women seeking to retain fertility, and women with asymptomatic fibroids—have particular treatment needs that require a variety of diagnostic methods and treatment options. Despite the widespread occurrence of uterine fibroids and newer treatment options, little high-quality data are available to formulate evidence-based guidelines that address these unmet patient needs. Specific areas in need of attention include improving diagnostic techniques, increasing patient access to early treatment, and identifying best practices for this diverse patient population.
126 citations
Thomas Jefferson University1, University of Illinois at Chicago2, Eastern Virginia Medical School3, University of Pennsylvania4, Cleveland Clinic5, University of Texas at Dallas6, Northwestern University7, University of Texas Health Science Center at Houston8, Columbia University9, AbbVie10, George Washington University11, Wayne State University12, Mayo Clinic13, SUNY Downstate Medical Center14
TL;DR: Elagolix with add-back therapy was effective in reducing heavy menstrual bleeding in women with uterine fibroids and Hypoestrogenic effects of elagolIX, especially decreases in bone mineral density, were attenuated withAdd- back therapy.
Abstract: Background Uterine fibroids are hormone-responsive neoplasms that are associated with heavy menstrual bleeding. Elagolix, an oral gonadotropin-releasing hormone antagonist resulting in rap...
124 citations
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TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
31,379 citations
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TL;DR: A checklist of items that should be addressed in Reports of Observational Studies in Epidemiology (STROBE) Statement, a general reporting recommendations for descriptive observational studies and studies that investigate associations between exposures and health outcomes is developed.
Abstract: Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalizability of its results. Taking into account empirical evidence and theoretical considerations, a group of methodologists, researchers, and editors developed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) recommendations to improve the quality of reporting of observational studies. The STROBE Statement consists of a checklist of 22 items, which relate to the title, abstract, introduction, methods, results, and discussion sections of articles. Eighteen items are common to cohort studies, case-control studies, and cross-sectional studies, and 4 are specific to each of the 3 study designs. The STROBE Statement provides guidance to authors about how to improve the reporting of observational studies and facilitates critical appraisal and interpretation of studies by reviewers, journal editors, and readers. This explanatory and elaboration document is intended to enhance the use, understanding, and dissemination of the STROBE Statement. The meaning and rationale for each checklist item are presented. For each item, 1 or several published examples and, where possible, references to relevant empirical studies and methodological literature are provided. Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated Web site (www.strobe-statement.org) should be helpful resources to improve reporting of observational research.
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TL;DR: In this article, the authors estimated the age-specific cumulative incidence of fibroid tumors for black and white women in the United States and found that most premenopausal women develop fibroid tumor before menopause.
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TL;DR: No studies have yet demonstrated that women on oral pills are at increased risk for growth of these tumors, and low-dose contraceptives should not be contraindicated in patients with leiomyomata if they desire to use this form of contraceptive.
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