Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma
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Cites background from "Epigenetic activation of the MiR-20..."
...Interactions are also coupled with miRNA binding site details [10]....
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Cites background from "Epigenetic activation of the MiR-20..."
...In addition, it downregulated the EMT key mediator, Twist1 (as opposed to its high positive correlation with H19 in the murine metastasis model of 4 T1 breast cancer cell line in which Twist was initially identified as a metastasis marker [74])....
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...Hernandez JM, Elahi A, Clark CW, Wang J, Humphries LA, Centeno B, et al. miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular carcinoma....
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...Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis....
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...However, in regard to the ZEB1–miR200 loop, H19 rather promotes the MET axis, apparently by interaction with a ribonucleoprotein complex that activates miR200 expression [93]....
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...Subsequently, miR-200 mediates H19 dependent down-regulation of Snail and Twist [93]....
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382 citations
Cites background from "Epigenetic activation of the MiR-20..."
...Furthermore high HOTAIR gene expression DD3 (PCA3) Prostate Upregulated Biomarker [43] HOTAIR Breast, hepatocellular, colorectal, gastrointestinal stromal Upregulated Biomarker [16,44-47] Oncogenic [16,48] MALAT1 Lung, hepatocellular Upregulated Biomarker [49-51] Lung, liver, renal cell, breast, cervical, uterine endometrial stromal, colorectal, bladder, osteosarcoma Oncogenic [52] H19 Hepatocellular Downregulated Biomarker [53] Hepatocellular, bladder Upregulated Oncogenic [54] PCAT-1 Prostate Upregulated Oncogenic [27] PCGEM1 Prostate Upregulated Oncogenic [55] TUC338 Hepatocellular Upregulated Oncogenic [56] BANCR Melanoma Upregulated Oncogenic [57] YIYA Hepatocellular, ovary, breast, esophageal Upregulated Oncogenic [58] CRNDE Colorectal, hepatocellular, pancreatic, prostate, ovarian, leukemia, gliomas Upregulated Oncogenic [59] CCAT1 Gastric Upregulated Oncogenic [60] HULC Hepatocellular Upregulated Oncogenic [61] CUDR Bladder Upregulated Oncogenic [62] GAS5 Breast Downregulated Tumor suppressive [63] linc-p21 Mouse models of lung, sarcoma, lymphoma Downregulated Tumor suppressive [29] MEG3 Meningioma, glioma, hepatocellular, leukemia Downregulated Tumor suppressive [64-67] PTENP1 Prostate, colon Downregulated Tumor suppressive [40] PTCSC3 Papillary thyroid Downregulated Tumor suppressive [68] is correlated with metastasis in these four types of cancers, poor survival rate in breast cancer, increasing risk of recurrence after hepatectomy in HCC and high-risk grade in GIST, indicating HOTAIR may be a useful biomarker of poor prognosis and tumor metastasis in these cancers [16,44-47]....
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...H19 Hepatocellular Downregulated Biomarker [53]...
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...More recently, it was reported that lncRNA H19 is underexpressed in intratumoral HCC tissues (T), as compared with peritumoral tissues (L), and low T/L ratio of H19 is associated with shorter disease-free survival and can be used to predict poor prognosis [53]....
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