Journal ArticleDOI
Epigenetic-based therapy for colorectal cancer: Prospect and involved mechanisms
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TLDR
A summary of valuable results that represent evidence of principle for epigenetic‐based therapeutic approaches employment in CRC with a focus on the advantages of epigenetic-based therapy in the inhibition of the CRC metastasis and proliferation.Abstract:
Epigenetic modifications are heritable variations in gene expression not encoded by the DNA sequence. According to reports, a large number of studies have been performed to characterize epigenetic modification during normal development and also in cancer. Epigenetics can be regarded more widely to contain all of the changes in expression of genes that make by adjusted interactions between the regulatory portions of DNA or messenger RNAs that lead to indirect variation in the DNA sequence. In the last decade, epigenetic modification importance in colorectal cancer (CRC) pathogenesis was demonstrated powerfully. Although developments in CRC therapy have been made in the last years, much work is required as it remains the second leading cause of cancer death. Nowadays, epigenetic programs and genetic change have pivotal roles in the CRC incidence as well as progression. While our knowledge about epigenetic mechanism in CRC is not comprehensive, selective histone modifications and resultant chromatin conformation together with DNA methylation most likely regulate CRC pathogenesis that involved genes expression. Undoubtedly, the advanced understanding of epigenetic-based gene expression regulation in the CRC is essential to make epigenetic drugs for CRC therapy. The major aim of this review is to deliver a summary of valuable results that represent evidence of principle for epigenetic-based therapeutic approaches employment in CRC with a focus on the advantages of epigenetic-based therapy in the inhibition of the CRC metastasis and proliferation.read more
Citations
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Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer.
Aitor Rodriguez-Casanova,Nicolás Costa-Fraga,Aida Bao-Caamano,Rafael López-López,Laura Muinelo-Romay,Angel Diaz-Lagares +5 more
TL;DR: In this article, the authors summarize current knowledge of the most relevant epigenetic mechanisms associated with cancer development and progression, and the implications of their deregulation in cancer cells and liquid biopsy of CRC patients.
Colorectal cancer tumour markers and biomarkers: Recenttherapeutic advances
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miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2
Yong-BinZheng,Hai-PingLuo,QiangShi,Zhi-NanHao,YuDing,Qiu-ShuangWang,Sheng-BoLi,Gao-ChunXiao,Shi-LunTong +8 more
TL;DR: It is indicated that miR-132 plays an important role in the invasion and metastasis of CRC.
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Prognostic and predictive values of CXCL10 in colorectal cancer
J. Chen,Qi-Long Chen,Wen-Hai Wang,Xiao-Le Chen,Xue-Qing Hu,Z.-Q. Liang,Y.-b. Cao,Y.-M. Cao,Shi-Bing Su +8 more
TL;DR: The study suggests that CXCL10 might be a potential target for the treatment of CRC, and significant associations were observed between CxCL10 and methylation and immune infiltration.
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Regulation of signal transduction pathways in colorectal cancer: implications for therapeutic resistance.
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TL;DR: The known histone modifications are described, where they are found genomically and discussed and some of their functional consequences are discussed, concentrating mostly on transcription where the majority of characterisation has taken place.
Journal ArticleDOI
Epigenetics in Cancer
TL;DR: The current understanding of alterations in the epigenetic landscape that occur in cancer compared with normal cells, the roles of these changes in cancer initiation and progression, including the cancer stem cell model, and the potential use of this knowledge in designing more effective treatment strategies are discussed.
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Fatima Haggar,Robin P. Boushey +1 more
TL;DR: The incidence, mortality, and survival rates for colorectal cancer are reviewed, with attention paid to regional variations and changes over time.
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