Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets
Filippo Caraci,Francesca Calabrese,Raffaella Molteni,Lucie Bartova,Markus Dold,Gian Marco Leggio,Chiara Fabbri,Julien Mendlewicz,Giorgio Racagni,Siegfried Kasper,Marco A. Riva,Filippo Drago +11 more
TL;DR: It is suggested that drug targeting different neurobiological systems should be able to restore normal function but must also promote resilience to reduce the long-term vulnerability to recurrent depressive episodes.
Journal ArticleDOI
Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus
Mi Kyoung Seo,Nguyen Ngoc Ly,Chan Hong Lee,Hye Yeon Cho,Cheol Min Choi,Le Hoa Nhu,Jung Goo Lee,Bong Ju Lee,Gyung Mee Kim,Bong June Yoon,Sung Woo Park,Young Hoon Kim +11 more
TL;DR: The results suggest that postnatal MS and subsequent adult RS modulate epigenetic changes in the BDNF gene, and that these changes may be related to behavioral phenotype, and these epigenetic mechanisms are involved in escitalopram action.
Journal ArticleDOI
Epigenetic learning in non-neural organisms
Simona Ginsburg,Eva Jablonka +1 more
TL;DR: Using toy models, it is shown that this characterization applies not only to the paradigmatic case of neural learning, but also to cellular responses that are based on epigenetic mechanisms of cell memory.
Journal ArticleDOI
Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model.
Paolo Petazzi,Juan Sandoval,Karolina Szczesna,O. Jorge,Laura Roa,Sergi Sayols,Antonio Gomez,Dori Huertas,Manel Esteller +8 more
TL;DR: The findings indicate that the transcriptional dysregulation of lncRNAs upon Mecp2 loss contributes to the neurological phenotype of Rett syndrome and highlights the complex interaction between ncRNAs and coding-RNAs.
Journal Article
Aging and stress: past hypotheses, present approaches and perspectives.
TL;DR: Results obtained with the use of the environmental enrichment model in animals and in humans suggest that positive environmental factors can help to maintain neuronal plasticity during aging and to protect the brain against the damaging effects of stress exposure.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.