Epigenetic codes in cognition and behaviour.
Citations
49 citations
Cites background from "Epigenetic codes in cognition and b..."
...…modulate enduring changes in gene expression to regulate memory formation and neural plasticity (Fischer, Sananbenesi, Wang, Dobbin, & Tsai, 2007; Gräff & Mansuy, 2008; Gupta et al., 2010; GuptaAgarwal, Jarome, Fernandez, & Lubin, 2014; Gupta-Agarwal et al., Please cite this article in press as:…...
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...…on epigenetics in cognition have focused on DNA methylation and histone H3 (de-)acetylation and have been summarized in excellent recent reviews (Gräff & Mansuy, 2008; Gräff, Woldemichael, Berchtold, Dewarrat, & Mansuy, 2012b; Miller et al., 2010; Penney & Tsai, 2014; Zovkic, GuzmanKarlsson, &…...
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48 citations
Cites background from "Epigenetic codes in cognition and b..."
...diverse aspects of nervous system development and function, such as dendritic development, synapse maturation, synaptic plasticity, learning, and memory (Fontan-Lozano et al., 2008; Gräff and Tsai, 2013; Graff and Mansuy, 2008; Jarome and Lubin, 2014; Jia et al., 2015; Pirooznia and Elefant, 2013)....
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45 citations
Cites background from "Epigenetic codes in cognition and b..."
...Depending on the type of epigenetic modification, this can result in actively transcribed or silenced genes (Graeff and Mansuy 2008; Sananbenesi and Fischer 2009)....
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...alterations in gene functions that are heritable through both mitosis and meiosis, but that cannot be explained by changes in the DNA sequence itself (Graeff and Mansuy 2008; Levenson and Sweatt 2005)....
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...Most commonly, epigenetic mechanisms are defined as alterations in gene functions that are heritable through both mitosis and meiosis, but that cannot be explained by changes in the DNA sequence itself (Graeff and Mansuy 2008; Levenson and Sweatt 2005)....
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44 citations
43 citations
References
11,123 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...These forms f plasticity reflect respectively, an increase and a decrease in he efficiency of synaptic transmission, and have been extenively studied in the hippocampus, a brain area required for earning and memory (for a review see [30])....
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10,046 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...Chronic xposure to an aggressor results in pronounced social avoidnce, prolonged downregulation of two splice variants of Bdnf, dnfIII and BdnfIV in the hippocampus and increased promoter imethylation of H3K27 [102], a mark of transcriptional represion [20]....
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9,309 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...These nzymes operate both independently and in synergy to establish “histone code”, a highly dynamic and flexible chromatin markng that, in combination with chromatin-associated proteins, etermines the pattern of gene expression in response to given xternal stimuli [24,25]....
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6,691 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...ecause of the covalent nature of the binding of methyl groups o the C5 carbon in cytosine, DNA methylation is thought to be he most stable epigenetic mark [9]....
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...DNA methylation is commonly associated with ranscriptional silencing because it can directly inhibit the bindng of transcription factors or regulators, or indirectly recruit ethyl-CpG binding proteins (MBPs), which have repressive hromatin-remodeling functions [9,10]....
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...Most cases of RS are caused by mutaions in the gene coding for methyl-CpG binding protein 2 MeCP2) [62], a member of the MBP family involved in ong-term gene silencing (for a review see [9])....
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5,760 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...ot be explained by changes in the DNA sequence itself [3] reviewed in [4,5])....
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