Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Journal ArticleDOI
Epigenetic regulation of cognition: A circumscribed review of the field.
TL;DR: An overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) is provided and their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions are discussed.
Alzheimer's disease: an evolutionary approach.
TL;DR: Approaching the disease from an evolutionary standpoint may help in understanding the root cause of human vulnerability to the disease, making AD a possible example of antagonistic pleiotropy.
Journal ArticleDOI
Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs.
TL;DR: Although still in its infancy, research investigating the effects of pharmacological modulation of epigenetic and microRNA mechanisms in neuropsychiatric disorders continues to provide encouraging findings, suggesting new avenues for treatment of mood and anxiety disorders.
Book ChapterDOI
The intergenerational effects of early adversity.
TL;DR: This work states that epigenetic mechanisms capable of explaining such phenomena were not available until relatively recently, with most of this research published only within the last decade.
Journal ArticleDOI
Epigenetic regulation of genes in learning and memory
TL;DR: Data regarding epigenetic marking of genes in adult learning and memory formation and impairment thereof is discussed, as well as data showcasing the promise for manipulating the epigenome in restoring memory capacity are discussed.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.