Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease.
TL;DR: Report that sporadic, late-onset of AD results from vascular etiology indicates that continuous formation of free ROS induces cellular damage and decreases antioxidant defenses, and oxidative stress increases vascular endothelial permeability and promotes leukocyte adhesion.
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The Path to Epigenetic Treatment of Memory Disorders
TL;DR: This review will begin with a brief exploration of recent advances in understanding of how epigenetic mechanisms contribute to learning and memory processes that are susceptible to failure and use parallels from the field of cancer to speculate on where epigenetics should be heading from here in the pursuit of therapeutics.
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Epigenetics: from the past to the present
TL;DR: The epigenome, as the bridge between the genome and the phenotype, is one of the most interesting current ideas in genetics and is so revolutionary that it may change present notions about inheritance and evolution.
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Association between pre-pregnancy overweight and obesity and children's neurocognitive development: a systematic review and meta-analysis of observational studies.
Celia Álvarez-Bueno,Iván Cavero-Redondo,Lidia Lucas-de la Cruz,Blanca Notario-Pacheco,Vicente Martínez-Vizcaíno,Vicente Martínez-Vizcaíno +5 more
TL;DR: Pre-pregnancy obesity might have negative consequences on the neurocognitive development of offspring, and the Mantel-Haenszel fixed-effects method was used to calculate pooled effect size values.
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Transgenerational effects of childhood conditions on third generation health and education outcomes.
TL;DR: Findings indicate that third generation males (females) tend to have higher mental health scores if their paternal grandfather (maternal grandmother) was exposed to a famine during the slow growth period.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.